It is best to read this information with our general information about non-Hodgkin lymphoma (NHL). If you have any more questions, you can ask your doctor or nurse at the hospital where you are having treatment.
Primary mediastinal large B-cell lymphoma (PMBCL) is a fast-growing type of NHL. It is also sometimes called primary thymic mediastinal lymphoma. It develops when the body makes abnormal B-cells (also called B-lymphocytes). B-cells are white blood cells that fight infection.
The abnormal B-cells (lymphoma cells) develop in a part of the lymphatic system called the thymus gland. They then build up in lymph nodes in the space behind the breast bone and between the lungs. This area is called the mediastinum. It contains:
- the gullet
- the windpipe
- the thymus
- the heart
- some large blood vessels
- some lymph nodes.