This can cause bleeding from the bladder, which means you may have blood in your urine (pee). This is called haematuria.
Mesna helps protect your bladder to prevent irritation and bleeding.
Mesna is always given with ifosfamide. Most people who have treatment with cyclophosphamide are not given high enough doses to cause bleeding from the bladder, so they do not need mesna.
But, if your treatment involves having high doses of cyclophosphamide you are given mesna.
Your doctor can tell you if you are having a high dose of cyclophosphamide.
While you are having mesna, your urine is tested for signs of blood. If you have blood in your urine, you will be given extra mesna.
You can help protect your bladder during treatment by:
- drinking plenty of water – usually at least 2 litres (3½ pints) each day
- emptying your bladder (peeing) often during the treatment.