If you are given ifosfamide chemotherapy, you may get blood in your urine (haematuria). This can also happen with higher doses of cyclophosphamide chemotherapy. Both drugs can cause irritation and bleeding from the lining of the bladder. Mesna helps prevent this by protecting your bladder lining.
Mesna is always given with ifosfamide and is normally given with higher doses of cyclophosphamide. While you're having this treatment, your urine is measured and tested for any signs of blood. If you have blood in your urine, you’ll be given extra mesna. Drinking plenty of water and emptying your bladder often during the treatment will also help to protect your bladder lining.