What is CVP?

CVP is a combination treatment used to treat non-Hodgkin lymphoma.

It is best to read this information with our general information about chemotherapy and the type of cancer you have.

CVP is named after the initials of the drugs used:

Your doctor will talk to you about this treatment and its possible side effects before you agree (consent) to have treatment.

How CVP is given

You will be given CVP in the chemotherapy day unit. A chemotherapy nurse will give it to you.

During treatment you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse, and a specialist pharmacist. This is who we mean when we mention doctor, nurse or pharmacist in this information.

Before or on the day of treatment, a nurse or person trained to take blood (phlebotomist) will take a blood sample from you. This is to check that your blood cells are at a safe level to have chemotherapy.

You will see a doctor or nurse before you have chemotherapy. They will talk to you about your blood results and ask you how you have been feeling. If your blood results are okay, the pharmacist will prepare your chemotherapy. Your nurse will tell you when your treatment is likely to be ready. 

Your nurse usually gives you anti-sickness (anti-emetic) drugs before the chemotherapy. The chemotherapy drugs can be given through: 

  • a short thin tube the nurse puts into a vein in your arm or hand (cannula)
  • a fine tube that goes under the skin of your chest and into a vein close by (central line)
  • a fine tube that is put into a vein in your arm and goes up into a vein in your chest (PICC line).
  • Your course of chemotherapy

    You usually have a course of several cycles of treatment over a few months. Your nurse or doctor will talk to you about how the treatment will be given. They may give you a copy of a treatment plan to take home with you.

    On day 1 the nurse will give you:

    • prednisolone as tablets 
    • cyclophosphamide as an injection into your cannula or line with a drip (infusion) to flush it through 
    • vincristine as a drip over 5 to 10 minutes, with fluids before and after it. 

    On days 2 to 5 you continue to take prednisolone at home. 

    You then have a rest period for 16 days before starting your next cycle.

    About side effects

    We explain the most common side effects of this treatment here. We also include some less common side effects.

    You may get some of the side effects we mention, but you are unlikely to get all of them. You may also have some side effects that we have not listed here. Always tell your doctor, nurse or pharmacist about any side effects you have.

    Your doctor can give you drugs to help control some side effects. It is important to take them exactly as your nurse or pharmacist explains. This means they will be more likely to work for you. Your nurse will give you advice about managing your side effects. After your treatment is over, most side effects start to improve.

    Serious and life-threatening side effects

    Some cancer treatments can cause severe side effects. Rarely, these may be life-threatening. Your cancer doctor or nurse can explain the risk of these side effects to you.

    Contact the hospital

    Your nurse will give you telephone numbers for the hospital. If you feel unwell or need advice, you can call them at any time of the day or night. Save these numbers in your phone or keep them somewhere safe.

    More information

    We cannot list every side effect for this treatment. There are some rare side effects that are not listed. You can visit the electronic Medicines Compendium (eMC) for more detailed information.

    Side effects while treatment is being given

    Some people may have side effects while they are being given the chemotherapy or shortly after they have it:

    Allergic reaction

    Some people have an allergic reaction while having this treatment. Signs of a reaction can include:

    • feeling hot or flushed
    • shivering
    • itching
    • a skin rash
    • feeling dizzy
    • a headache
    • feeling breathless or wheezy
    • swelling of your face or mouth
    • pain in your back, tummy or chest.

    Your nurse will check you for signs of a reaction during your treatment. If you feel unwell or have any of these signs, tell them straight away. If you do have a reaction, it can be treated quickly.

    Sometimes a reaction happens a few hours after treatment. If you develop any signs or feel unwell after you get home, contact the hospital straight away.

    The drug leaks outside the vein

    The drug may leak outside the vein. If this happens it can damage the surrounding tissue. This is called extravasation. Extravasation is not common but if it happens it is important to treat it quickly. Tell your nurse straight away if you have any stinging, pain, redness or swelling around the vein.

    Common side effects

    Risk of infection

    This treatment can reduce the number of white blood cells in your blood. These cells fight infection. If the number of white blood cells is low, you are more likely to get an infection. A low white blood cell count is sometimes called neutropenia.

    An infection can be very serious when the number of white blood cells is low. It is important to get any infection treated as soon as possible. Contact the hospital straight away on the 24-hour contact number you have been given if:

    • your temperature goes over 37.5°C (99.5°F)
    • you suddenly feel unwell, even with a normal temperature
    • you have symptoms of an infection
    • your temperature goes below 36°C (96.8°F).

    Symptoms of an infection include:

    • feeling shivery and shaking
    • a sore throat
    • a cough
    • breathlessness
    • diarrhoea
    • needing to pass urine (pee) a lot, or discomfort when you pass urine.

    It is important to follow any specific advice your cancer treatment team gives you.

    The number of white blood cells will usually return to normal before your next treatment. You will have a blood test before having more treatment. If your white blood cell count is low, your doctor may delay your treatment for a short time, until your cell count increases.

    Bruising and bleeding

    This treatment can reduce the number of platelets in your blood. Platelets are cells that help the blood to clot.

    If the number of platelets is low, you may bruise or bleed easily. You may have:

    • nosebleeds
    • bleeding gums
    • heavy periods
    • blood in your urine (pee) or stools (poo)
    • tiny red or purple spots on the skin that may look like a rash.

    Tell your doctor if you have any unexplained bruising or bleeding. You may need a drip to give you extra platelets. This is called a platelet transfusion.

    Anaemia (low number of red blood cells)

    This treatment can reduce the number of red blood cells in your blood. Red blood cells carry oxygen around the body. If the number of red blood cells is low, this is called anaemia. You may have symptoms such as:

    • pale skin
    • lack of energy
    • feeling breathless
    • feeling dizzy and light-headed.

    Tell your doctor or nurse if you have these symptoms.

    If you are very anaemic, you may need a drip to give you extra red blood cells. This is called a blood transfusion.

    Feeling sick

    Your doctor will give you anti-sickness drugs to help prevent or control sickness during your treatment. Take the drugs exactly as your nurse or pharmacist tells you. It is easier to prevent sickness than to treat it after it has started.

    If you feel sick, take small sips of fluids often and eat small amounts regularly. It is important to drink enough fluids. If you continue to feel sick, or are sick (vomit) more than once in 24 hours, contact the hospital as soon as possible. They will give you advice. Your doctor or nurse may change the anti-sickness drug to one that works better for you.

    Feeling tired

    Feeling tired is a common side effect of this treatment. It is often worse towards the end of treatment and for some weeks after it has finished. Try to pace yourself and plan your day so you have time to rest. Gentle exercise, like short walks, can give you more energy.

    If you feel sleepy, do not drive or use machinery.

    Hair loss

    Your hair will get thinner. Or you may lose all the hair from your head. You may also lose your eyelashes and eyebrows, as well as other body hair. Hair loss usually starts after your first or second treatment.

    Your nurse can talk to you about ways to cope with hair loss. There are ways to cover up hair loss if you want to. Your scalp may be sensitive. It is important to cover your head to protect your skin when you are out in the sun.

    Hair loss is almost always temporary. Your hair will usually grow back after treatment finishes.


    This treatment can cause constipation. Constipation means that you are not able to pass stools (poo) as often as you normally do. It can become difficult or painful. Here are some tips that may help:

    • Drink at least 2 litres (3½ pints) of fluids each day.
    • Eat high-fibre foods, such as fruit, vegetables and wholemeal bread.
    • Do regular gentle exercise, like going for short walks.

    If you have constipation, contact the hospital for advice. Your doctor can give you drugs called laxatives to help.

    Sore mouth and throat

    This treatment may cause a sore mouth and throat. You may also get mouth ulcers. This can make you more likely to get a mouth or throat infection. Use a soft toothbrush to clean your teeth or dentures in the morning, at night and after meals.

    If your mouth or throat is sore:

    • tell your nurse or doctor – they can give you a mouthwash or medicines to help
    • try to drink plenty of fluids
    • avoid alcohol, tobacco, and foods that irritate your mouth and throat.

    Sucking ice chips may sometimes help relieve mouth or throat pain. But if you are having radiotherapy to the head or neck, do not suck on ice. It can cause damage.

    Bladder irritation

    Cyclophosphamide may irritate your bladder and cause discomfort when you pass urine (pee). Drink plenty of fluids – at least 2 litres (3 ½ pints) during the first 24 hours following chemotherapy. It is important to empty your bladder often. You should try to pass urine as soon as you feel the need to go. Contact the hospital straight away if you:

    • find it hard to pass urine
    • feel any discomfort or stinging when you pass urine
    • notice any blood in your urine.

    Numb or tingling hands or feet (peripheral neuropathy)

    This treatment affects the nerves, which can cause numb, tingling or painful hands or feet. You may find it hard to fasten buttons or do other fiddly tasks.

    Tell your doctor if you have these symptoms. They sometimes need to lower the dose of the drug. The symptoms usually improve slowly after treatment finishes, but for some people they may never go away. Talk to your doctor if you are worried about this.

    Raised blood sugar levels

    Steroids can raise the levels of sugar in your blood. Your nurse will check your blood regularly for this. They may also test your urine for sugar. Symptoms of raised blood sugar include:

    • feeling thirsty
    • needing to pass urine (pee) more often
    • feeling tired. 

    Tell your doctor or nurse if you have these symptoms.

    If you have diabetes, your blood sugar levels may be higher than usual. Your doctor will talk to you about how to manage this. You may need to adjust the dose of your insulin or diabetes tablets.

    Tummy pain or indigestion

    Steroids can irritate the stomach lining. Let your nurse or doctor know if you have indigestion or pain in your tummy. They can prescribe drugs to help reduce stomach irritation.

    You should take your tablets with food to help protect your stomach. Some steroid tablets are coated to help reduce irritation.

    Increased appetite

    Steroids can make you feel hungrier than usual and you may gain weight. Your appetite will go back to normal when you stop taking them. If you are worried about gaining weight, talk to your doctor or nurse.

    Build-up of fluid

    Prednisolone may make you put on weight. Your ankles and legs may swell because of fluid building up. This is more common if you are taking prednisolone for a long time. Tell your doctor or nurse if fluid builds up. If your ankles and legs swell it can help to put your legs up on a foot stool or cushion. The swelling gets better after your treatment ends.

    Mood and behaviour changes

    Steroids can affect your mood. You may:

    Taking your steroids in the morning may help you sleep better.

    Tell your doctor or nurse if you have any of these side effects. They may make some changes to your treatment if the side effects become a problem.

    Skin changes

    This treatment may affect your skin. It may cause a rash, which might be itchy. Your doctor or nurse can tell you what to expect. If your skin feels dry, try using an unperfumed moisturising cream every day.

    Always tell your doctor or nurse about any changes to your skin. They can give you advice and may prescribe creams or medicines to help. Skin changes usually improve when treatment finishes.

    Nail changes

    This treatment can affect your nails. They may grow more slowly or break more easily. You might notice ridges or white or dark lines across your nails. Sometimes nails can become loose or fall out. When treatment finishes, any changes usually disappear as the nails grow out.

    There are things you can do to look after your nails:

    • Moisturise your nails and cuticles regularly.
    • Keep your nails clipped short.
    • Wear gloves to protect your nails when you are doing things in the house or garden.
    • Keep your hands and nails clean to help avoid infection, but avoid bathing in very hot water.
    • Do not use false nails, gels or other acrylics during this treatment, as they may increase the risk of infection.
    • It is fine to wear nail varnish, but try to use a water-based polish. Avoid using harsh chemicals, such as acetone, when taking off the polish.
    • If your toenails are affected, wear well-fitted shoes to cushion them.

    Tell your doctor or nurse if you notice changes to your nails. They can give you advice or arrange for you to see a podiatrist for foot care advice if needed.

    Raised levels of uric acid (tumour lysis syndrome)

    This treatment may cause the cancer cells to break down quickly. This releases a waste product called uric acid into the blood. The kidneys usually get rid of it, but they may not be able cope with large amounts. Too much uric acid can cause swelling and pain in the joints. This is called gout.

    Your doctor may give you allopurinol tablets to help prevent gout. Drinking at least 2 litres (3½ pints pints) of fluids a day will help. You will have regular blood tests to check the level of uric acid in your blood.

    Jaw pain

    Vincristine may cause pain in your jaw. If you notice this, tell your nurse or doctor.

    Changes in the way the liver works

    CVP may affect how your liver works. This is usually mild and goes back to normal after treatment. You will have blood tests to check how well your liver is working.

    Less common side effects

    Effects on the heart

    This treatment can affect how the heart works. You may have tests to see how well your heart is working. These may be done before, during and after treatment.

    If the treatment is causing heart problems, your doctor may change the type of treatment you are having.

    Contact your doctor straight away on the 24-hour number the hospital has given you if you have any of these symptoms during or after treatment:
    • pain or tightness in your chest
    • breathlessness
    • dizziness
    • changes to your heartbeat.

    Other conditions can cause these symptoms, but it is important to get them checked by a doctor. If you cannot get through to your doctor, call the NHS urgent advice number on 111.

    Effects on the lungs

    This treatment can cause changes to the lungs. Tell your doctor if you develop:

    • a cough
    • wheezing
    • breathlessness.

    You should also tell them if any existing breathing problems get worse. You may have tests to check your lungs.

    Changes to the ear and hearing

    This treatment may affect the ear and cause hearing changes. You may have ringing in the ears, called tinnitus. You may also become unable to hear high-pitched sounds. Hearing changes usually get better after treatment ends. But some can be permanent.

    Changes to the ear can also cause dizziness or affect your balance. Tell your doctor if you notice any of these changes. They may make changes to your treatment. It is important not to drive if you feel dizzy or unsteady. 

    Second cancer

    This treatment can increase the risk of developing a second cancer years later. This is rare. The benefits of treatment usually far outweigh this risk. Your doctor can talk to you about this.

    Other information

    Blood clot risk

    Cancer and some cancer treatments can increase the risk of a blood clot. Symptoms of a blood clot include:

    • throbbing pain, redness or swelling in a leg or arm
    • suddenly feeling breathless or coughing
    • sharp chest pain, which may be worse when you cough or take a deep breath.

    If you have any of these symptoms, contact the hospital straight away on the 24-hour contact number you have been given. If you cannot get through to your doctor, call the NHS urgent advice number on 111.

    A blood clot is serious, but it can be treated with drugs that thin the blood (anticoagulants). Your doctor or nurse can give you more information.

    You can help reduce the risk of developing a blood clot by:

    • staying active during treatment
    • drinking plenty of fluids, especially water.

    You may be given anticoagulants to help prevent a clot.

    Other medicines

    Some medicines can affect how this treatment works or be harmful when you are having it. Always tell your cancer doctor about any drugs you are taking or planning to take, such as:

    • medicines you have been prescribed
    • medicines you buy in a shop or chemist
    • vitamins, herbal drugs and complementary therapies.

    Tell other doctors, pharmacists or dentists who prescribe or give you medicines that you are having this cancer treatment.

    You can visit the electronic Medicines Compendium (eMC) for more detailed information about your treatment.


    Vaccinations can reduce your risk of getting certain infections. Your doctor or nurse may talk to you about having vaccinations.

    Doctors usually recommend that people with cancer have a flu vaccination and a coronavirus (covid) vaccination. These are both inactivated vaccinations that can help reduce the risk of infection. People with weak immune systems can have these, as they are not live vaccinations. 

    If your immune system is weak, you need to avoid live vaccinations. This is because they can make you unwell. Live vaccines contain a very weak version of the illness they are vaccinating you against. Your cancer doctor or GP can tell you more about live and inactivated vaccinations.


    Some cancer drugs can affect whether you can get pregnant or make someone pregnant. If you are worried about this, it is important to talk with your doctor before you start treatment.


    If you have sex in the first few days after this treatment, you should use barrier protection such as a condom or dental dam. This will protect your partner if any of the drug is in your semen or vaginal fluids.


    Your doctor will advise you not to get pregnant or make someone pregnant while having this treatment. The drugs may harm a developing baby. It is important to use contraception during your treatment and for a while after treatment finishes. Your doctor, nurse or pharmacist can tell you more about this.


    You are advised not to breastfeed while having this treatment, or for some time after treatment finishes. This is because the drugs could be passed to the baby through breast milk.

    Your doctor or nurse can give you more information.

    Medical and dental treatment

    If you need medical treatment for any reason other than cancer, always tell the doctors and nurses you are having cancer treatment. Give them the contact details for your cancer doctor so they can ask for advice.

    If you think you need dental treatment, talk to your cancer doctor or nurse. Always tell your dentist you are having cancer treatment.