Ovarian cancer

The ovaries are 2 small, oval-shaped organs in the pelvis (lower area between the hips). They are on either side of the womb (uterus), close to the fallopian tubes. These link the ovaries to the womb. A layer of tissue called the peritoneum supports the ovaries.

About 7,400 women are diagnosed with cancer of the ovary (ovarian cancer) each year in the UK.

The surface of the ovaries, fallopian tubes and peritoneum are very close together. Doctors think most ovarian cancers start in the cells at the end of the fallopian tube and travel to the ovaries or the peritoneum.

Cancers of the ovary, fallopian tube and of the peritoneum are often grouped together because they are so similar. They are treated in the same way.

Ovarian cancer can affect anyone who has ovaries and fallopian tubes. This includes women, transgender (trans) men and people assigned female at birth.

Cancer of the ovary causes symptoms like other more common and less serious conditions. This can make it more difficult to diagnose it early. Symptoms can include a swollen tummy and pain in the back or lower tummy.

Your GP asks about your symptoms and does an internal vaginal examination to check for any lumps or swelling. They usually arrange the following tests:

• a CA125 blood test to check for raised levels of this protein, which may be higher in ovarian cancer
• ultrasound scans to check the organs in the pelvis and tummy area.

If the ultrasound shows any abnormal areas, your GP arranges for you to see a specialist doctor (a gynaecological cancer specialist). You should be seen within 2 weeks.

If a GP finds a lump in your pelvis or fluid in your tummy (ascites), they refer you to a specialist straight away.

Sometimes ovarian cancer is diagnosed after being admitted to hospital with a symptom that is making you unwell.

Your specialist doctor will usually ask about:

• your general health
• any previous health problems
• any history of cancer in your family.

They do another internal examination. If you have not had a CA125 blood test and an ultrasound scan the doctor will arrange these tests for you.

Risk of Malignancy Index (RMI)

Your doctor may use your test results to check your Risk of Malignancy Index (RMI) score. This system checks how likely it is your symptoms are caused by cancer.

RMI looks at:

• whether you have gone through menopause
• the levels of CA125 in your blood
• the results of your ultrasound.

Your specialist doctor arranges further tests. These help to diagnose the cancer and plan your treatment. You may have:

Waiting for tests results can be a difficult time. We have more information that may help.

A team of specialists will meet to discuss the best possible treatment for you. This is called a multidisciplinary team (MDT).

Your cancer doctor and specialist nurse will explain the different treatments and their side effects. They will also talk to you about the things you should consider when making treatment decisions.

The main treatments are:

You may have some treatments as part of a clinical trial.

We have more information about how different treatments are used to treat treat ovarian cancer.

It can be very hard to hear that the cancer has come back again. You may feel shocked and find it difficult to think of having treatment again. Your doctor and specialist nurse are there to help and support you. They will explain the best treatment options for you. The aim is to control the cancer for as long as possible. Your treatment will depend on:

• the treatment you had before
• how long it kept the cancer away
• if you had any difficult side effects from previous treatments.

You usually have more chemotherapy and a targeted therapy drug. Sometimes further surgery is possible. You may have different treatments over several years to control the cancer. Your doctor may also talk to you about having newer treatments in a clinical trial.

Other cancer treatments are occasionally used:

Treatments for the cancer often improve any symptoms you have. If the cancer is more advanced you may see a specialist doctor or nurse for expert help in managing symptoms. We have more information about coping with advanced cancer.

Sometimes advanced ovarian cancer causes symptoms because of a build-up of fluid:

• in the tummy (called ascites)
• in the lung (called a pleural effusion) if the cancer has spread to the lung.

Your doctor will arrange to have the fluid drained away. After this you will feel more comfortable and less breathless.

Blocked bowel (bowel obstruction)

If the cancer is growing close to the bowel, it may put pressure on the bowel. This can cause a blockage so the bowel contents cannot easily pass through. Or it may happen because surgery to the abdomen causes tissues to stick together (called adhesions).

Symptoms can include:

• tummy pain
• bloating
• feeling sick
• vomiting large amounts
• constipation
• diarrhoea.

There are different ways it can be managed. Your doctor and nurse will talk this over with you. Treating the cancer may improve a bowel obstruction. But sometimes you may need surgery to remove the blocked section of bowel.

A blocked bowel can also be managed by having fluids through a drip for a time. Sometimes your doctor may suggest having nutrients through a tube, either into the stomach (enteral nutrition) or into a vein (parenteral nutrition).

We want everyone affected by cancer to feel our information is written for them.

We try to make sure our information is as clear as possible. We use plain English, avoid jargon, explain any medical words, use illustrations to explain text, and make sure important points are highlighted clearly.

We use gender-inclusive language and talk to our readers as ‘you’ so that everyone feels included. Where clinically necessary we use the terms ‘men’ and ‘women’ or ‘male’ and ‘female’. For example, we do so when talking about parts of the body or mentioning statistics or research about who is affected. Our aims are for our information to be as clear and relevant as possible for everyone.

You can read more about how we produce our information here.