What is a pleural effusion?

The lungs are covered by a lining (membrane) called the pleura. The pleura has 2 layers:

  • The inner layer is called the visceral pleura, which covers the lungs.
  • The outer layer is called the parietal pleura, which lines the ribcage and a sheet of muscle called the diaphragm. The diaphragm separates the chest from the tummy (abdomen).

Between the 2 layers of the pleura is a small amount of fluid that acts as a lubricant. It allows the lungs to move in and out smoothly and helps you to breathe easily. Sometimes, too much of this fluid builds up between the 2 layers of the pleura. This is called a pleural effusion.

Causes of a pleural effusion

A pleural effusion is common and is often caused by:

  • lung infections, such as pneumonia
  • heart failure, which is when the heart is not pumping blood around the body as well as it should.

A pleural effusion can also be a symptom of several types of cancer. An effusion can develop if cancer cells have spread into the pleura. They can lead to irritation and cause fluid to build up. The types of cancer that are more likely to cause a pleural effusion are:

Signs and symptoms of a pleural effusion

Common symptoms of a pleural effusion include:

  • breathlessness
  • a cough
  • chest pain.

The build-up of fluid presses on the lung, making it difficult for the lung to expand fully. This can make you more breathless, even when resting. You may also get some chest pain and a cough.

In some situations, part, or all, of the lung will collapse. Usually, when you breathe out there is still some air left in your lungs. But if the lung has collapsed, there is no air left in that part of the lung.

If you are worried about any symptoms, speak to your cancer team or your GP.

Diagnosing a pleural effusion

You may have a chest x-ray or an ultrasound scan, or both. Sometimes you need other tests to confirm the diagnosis, and the cause of the effusion.

Managing a pleural effusion

A pleural effusion can be managed by removing (draining) the fluid. This can help relieve symptoms.

Draining a small pleural effusion

If there is only a small amount of pleural fluid in the chest, the doctor may insert a small needle or thin tube (cannula) into the chest. They will use a syringe to remove the fluid. After the fluid has drained, the tube is taken out and the area is covered with a dressing.

Draining a pleural effusion with a chest drain

A pleural effusion is usually drained by putting a tube into the chest. This is called a chest drain. It is put in by a doctor or sometimes a specially trained nurse. They will ask you to sit on a chair, or on the edge of the bed. You will be asked to lean forward over a pillow on a table, so your back is showing.

Your doctor usually puts the tube in the side of the chest. They clean the skin with an antiseptic. They then give you an injection of local anaesthetic to numb the area. You will not feel any pain during the procedure. Sometimes it is done under general anaesthetic, which means you will be asleep.

Your doctor makes a very small cut in the chest. They then put the chest drain into the space where the fluid is collecting. Sometimes they use an ultrasound scan to help guide the tube into the correct position. When the tube is in position, they attach the chest drain to a bag or bottle for the fluid to drain into. The fluid that drains may have a small amount of blood in it.

Pleural effusion with drainage

An illustration showing the lungs in the chest. The person’s left lung has fluid between the inner pleura and the outer pleura. This is called a pleural effusion. A small bag is attached to the lung by a thin tube. The fluid is draining into the bag.
Image: The illustration shows the lungs in the chest. It shows the windpipe (trachea) coming down from the neck into the chest. About halfway down the chest, the windpipe divides into two tubes. One tube goes into the left lung. The other tube goes into the right lung. There are ribs around the outer side of each lung. Underneath the lungs and going across the width of the body is a muscle called the diaphragm. Surrounding each lung is a thin lining (membrane), which has two layers. This is called the pleura. The layer closest to each lung is called the inner pleura. The layer which lines the chest wall is called the outer pleura. There is a small space between the two layers of the pleura. This space is called the pleural cavity. Fluid has built up between the two layers of the left lung. This means the lung is smaller. The fluid is called a pleural effusion. The tip of a thin tube is shown going through the skin and between two ribs, into the fluid near the bottom of the left lung. Outside the body, this tube is attached to another tube which goes into a bag. The fluid is draining from the left lung and down these tubes into a drainage bag outside of the body.

Fluid is usually drained slowly. This is because a sudden release of pressure in the chest can cause your blood pressure to drop. 1 litre (about 2 pints) of fluid may be drained safely as soon as the drain has been put in. After this, it must be done more slowly. Your blood pressure is checked during the procedure. Tell your doctor or nurse if you feel dizzy, sick or light-headed.

In many hospitals, you can have this done as a day patient by a specialist lung team. Sometimes, you may need to stay in hospital for around 2 days or sometimes longer. This may happen, for example, if it is taking longer for the fluid to drain or if there are any complications.

You may have some pain when the local anaesthetic wears off. Tell your doctor or nurse if this happens. They can prescribe painkillers to help.

The drainage tube is held in place with a small stitch until the fluid has drained. If your drainage tube is attached to a bottle or bag, you will be able to walk about with it. The chest drain may feel uncomfortable at times. Tell your doctor or nurse if it is very uncomfortable.

It is important to be careful with the bottle or bag. It should not be raised above the level of your chest, as the fluid could go back into your lungs.

When the drainage has slowed down, you will have a chest x-ray to see how well your lung has re-expanded. If it has expanded well, the doctor or nurse will remove the drain.

Possible complications

  • Blocked drain

    This is rare and can sometimes be cleared by you changing your position or sitting up straight. Sometimes, the drain may need to be replaced.

  • Infected drain

    The staff will check your temperature for any sign that you are developing an infection.

  • Breathlessness and sharp pain in chest (pneumothorax)

    Sometimes when the fluid is drained from the chest, the lung cannot re-expand to fill the chest cavity. This leaves an air-filled space around the lung. This is called a pneumothorax. If it is a small pneumothorax, you may not need any treatment and it is likely to clear over a few days. You may need to have an x-ray to check it is gone. If it is a larger pneumothorax, you may need to have another drainage tube put in to remove the air.

  • The fluid can collect again

    If fluid builds up again, you may need to have the effusion drained more than once. To stop the fluid from building up again, your doctor may recommend other types of treatment. This may be chemotherapy or hormonal therapy, depending on the type of cancer. Your doctor may also advise you to have a pleurodesis or a thoracoscopy – these are explained in the next section.

If a pleural effusion comes back

If the fluid builds back up again, there are different ways to manage it.

Draining a pleural effusion at home (tunnelled indwelling pleural catheter)

If fluid keeps building up, it is possible to have repeated chest drains put in. But this can be uncomfortable and may mean lots of trips to the hospital.

It may be possible for you to have a special catheter put in. This is called a tunnelled indwelling pleural catheter (TIPC). This means you can drain your pleural effusion easily at home. When you have a build-up of fluid on the lung, the TIPC allows you to drain the fluid into a bottle. This can be done by you or a family member, or a community nurse if you do not feel comfortable doing it.

The catheter is inserted in hospital on a day ward. If there are no complications, you can usually go home on the same day.

Your doctor or specialist nurse can tell you more about this and if it is suitable for you.

Talc pleurodesis for a pleural effusion

It may be possible to seal the 2 layers of the pleura together. This can help stop the fluid from building up again. This is called talc pleurodesis. If the lung re-inflates after the fluid has been drained, sterile talcum powder (talc) can be used to help stick the pleura together.

The doctor puts the talc through the tube attached to the drain and then leaves the drain clamped for about an hour. This allows time for the 2 linings of the lung to stick together. The doctor may attach the drain to a suction machine to apply a small amount of pressure. This can help the pleura to seal together. After a pleurodesis, you will usually have the drain in place for another 24 hours.

If there is a stitch that has been holding the drain in place, a doctor or nurse will pull this together when the drain is removed. This closes the hole. They will cover it with a dressing. The stitch is usually removed about a week later. Sometimes just a dressing is used to cover the area where the drain has been.

After a pleurodesis, you may get chest pain for a day or so and you may need to take painkillers. Some people may also get a shivery flu-like symptom. Your doctor or nurse can give you more information about pleurodesis. If you have any signs of an infection such as a high temperature or feeling unwell, tell your doctor or nurse straight away.

Thoracoscopy for a pleural effusion

Sometimes you can have a pleural effusion drained during a thoracoscopy. The doctor puts a flexible tube (thoracoscope) into the chest. The tube has a light and camera at the end, so the doctors can see into your chest. Sometimes the doctor may also take a small sample of the lining of your lung (biopsy). This helps to diagnose why the fluid is building up.

For this, you lie on your side. You are given an injection of a sedative to make you feel drowsy. You also have a local anaesthetic to numb the area. Sometimes it may be done under general anaesthetic.

The doctor makes 1 or 2 small cuts to put the thoracoscope in. The procedure takes about 40 to 60 minutes.

They can also do talc pleurodesis during this to help reduce the risk of fluid building back up again.

After the thoracoscopy, the doctors put a plastic tube (chest drain) through the cut. They use this to drain any remaining fluid. The drain is attached to a bottle or bag and secured in place with a stitch.

You can usually go home 2 to 5 days after a thoracoscopy. Some people may be able to have it and go home on the same day. Your hospital team can give you more information about this procedure.

About our information

This information has been written, revised and edited by Macmillan Cancer Support’s Cancer Information Development team. It has been reviewed by expert medical and health professionals and people living with cancer.

  • References

    Below is a sample of the sources used in our mesothelioma cancer information. If you would like more information about the sources we use, please contact us at informationproductionteam@macmillan.org.uk

     

    Kusamura S, Kepenekian V, Villeneuve L, Lurvink RJ, Govaerts K, De Hingh IHJT, Moran BJ, Van der Speeten K, Deraco M, Glehen O; PSOGI. Peritoneal mesothelioma: PSOGI/EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Eur J Surg Oncol. 2021 Vol, 47(1) pp6-59. [accessed April 2024].

     

    Popat, S., Baas P., Faivre-Finn, C., Girard, N., Nicholson, A., Nowak, A., Opitz, I., Scherpereel, A, and Reck, M. 2021. ESMO Pleural mesothelioma guidelines. Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Available from: https://www.annalsofoncology.org/action/showPdf?pii=S0923-7534%2821%2904820-1 [accessed April 2024].

Dr David Gilligan SME

Dr David Gilligan

Reviewer

Consultant Clinical Oncologist

Addenbrookes Hospital, Cambridge

Date reviewed

Reviewed: 01 February 2025
|
Next review: 01 February 2028
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