Eye cancer (ocular melanoma)

Eye cancer is rare. There are different types of cancer that can affect the eye. Eye (ocular) melanoma is the most common type of cancer that starts in the eye.

Eye melanoma does not always cause any symptoms and may be found by an optician during a routine eye test. Signs and symptoms can include:

  • blurred vision
  • seeing flashing lights and shadows
  • brown or dark patches on the white area of the eye.

These symptoms can be caused by other eye conditions, but it is good to get them checked by your doctor or optician.

If you are diagnosed with eye melanoma, you will have further tests to find out the stage and grade of the cancer. This helps doctors plan the best treatment for you. The aim of treatment is to destroy the cancer cells, while doing as little damage to your eyesight as possible.

It is natural to feel many different emotions after a diagnosis. It may help to talk to someone close to you or to one of our cancer support specialists.

What is eye melanoma?

Eye cancer is rare. There are a number of different cancers that can affect the eye. Eye (ocular) melanoma is the most common and this information is about this type.

Melanoma is a cancer that develops from cells called melanocytes. Melanocytes give our skin its colour. Melanoma usually develops in the skin. But because there are melanocytes in different parts of the body, it can start in other places, such as the eye.

Most eye melanomas start in an area of the eye called the uvea (see below). This is called uveal melanoma. It is the most common type of cancer to affect the eye, although it is still quite rare. Between 500 and 600 people are diagnosed with uveal melanoma in the UK each year. It is more common in people over the age of 50.

Very rarely, melanoma starts in the conjunctiva, which is the outer lining of the eye. This is called conjunctival melanoma.

These two types of eye melanoma are treated in slightly different ways.


The eye

The eye is made up of several layers of tissue and filled with a clear jelly. Each part of the eye does an important job that helps us see.

The uvea is the middle layer inside the eyeball. It includes the choroid, the ciliary body and the iris, which is the coloured disc at the front of the eye. The iris controls how light comes into the eyeball through the pupil and helps the eye to focus.

The conjunctiva is a thin, clear lining that covers and protects the white outer surface of the eye and the inside of the eyelids.

The structure of the eye
The structure of the eye

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Causes and risk factors of eye melanoma

The cause of eye melanoma is not known. The main risk factor for skin melanoma is exposure to ultraviolet (UV) rays. This can be through natural light from the sun, or through artificial light used in sunbeds or sunlamps. But it is still not clear whether there is a link between UV ray exposure and eye melanoma.

Eye melanoma is more common in people with:

  • light-coloured hair or red hair
  • blue eyes
  • skin that burns easily.

Eye melanoma is also more common in people who have atypical mole syndrome, which is also called dysplastic naevus syndrome. People with this condition often have more than 100 moles on their body and are more likely to develop a skin melanoma.

Conjunctival melanoma usually develops from a rare condition called primary acquired melanosis (PAM), which causes brown or dark patches (pigmentation) on the conjunctiva. Sometimes the melanoma will develop from an existing freckle or mole on the conjunctiva.


Signs and symptoms of eye melanoma

Eye melanoma does not always cause any symptoms. It may be found by an optician during a routine eye test. Signs and symptoms can include:

  • blurred vision
  • seeing flashing lights and shadows
  • brown or dark patches on the white area of the eye.

These symptoms can be caused by other eye conditions, but tell your GP or optician if you notice them.


Diagnosing eye melanoma

You usually start by seeing your optician or GP. If they are unsure what the problem is, they will refer you to an eye specialist doctor (ophthalmologist) at the hospital.

During your appointment at the hospital, the specialist doctor will examine you. They may use the following tests to diagnose eye melanoma.

Eye drops

The doctor may put eye drops in your eye before or during some of these tests. This opens up (dilates) your pupil and makes it easier to look at your eyes. The effect lasts for about 4 to 8 hours. The drops will make your eyesight blurry during this time. Don’t drive until your eyesight returns to normal. You may want to ask someone to go to the hospital with you, so they can help you get home.

You may also find bright lights uncomfortable for a few hours. Wearing sunglasses can help with this.

Checking your eye

The doctor looks at the inside of your eye using a small, handheld lens and light (ophthalmoscope). Or they may use a larger microscope that sits on a table (slit-lamp biomicroscope), which you look into. They may put eye drops in your eye to open up your pupil.

Ultrasound scan

This scan uses sound waves to build up a picture on a computer screen of the inside of your eye and nearby areas. The doctor gently presses a small device against your closed eyelid and moves it over the skin. This is painless and usually only takes a few minutes.

Optical coherence tomography (OCT) scan

This scan uses laser light to look at the structure of the eye and produce an image of it. This image can show small changes in the layers of the eye, which can help with diagnosis. The scan is like having a special photograph taken. It is painless and takes only a few minutes.

Fluorescein angiography

The doctor uses this test to look at the circulation in the blood vessels of your eye. The doctor will first put eye drops in your eye to open up your pupil. They then inject a dye, called fluorescein, into a vein in your arm. The doctor uses a special camera to take photos of the dye as it moves through the blood vessels at the back of your eye.

Your body or face may feel warm for a short time after the injection. After the test, your urine will be bright yellow and your skin may be slightly yellow. This is caused by the dye. It is harmless and only lasts a few days.

Biopsy

Doctors can often diagnose eye melanoma by looking at the eye with the tests we mention above. But some people may need to have a small piece of tissue or cells removed from the eye using a fine needle. This is called a biopsy. You are more likely to have a biopsy if your specialist thinks you may have a conjunctival melanoma.

A biopsy is only done by expert eye doctors who can do it quickly and without causing you pain. You can have it done using a local anaesthetic or with a general anaesthetic.

Afterwards, a pathologist will look at the tissue under a microscope to look for cancer cells or conditions that may develop into melanoma, if left untreated. A pathologist is a doctor who specialises in analysing cells.


Further tests for eye melanoma

You may have other tests to help plan your treatment or to check how effective treatment has been.

Transillumination

If you need surgery, this test shows exactly where the melanoma is and helps the doctor plan the operation. The doctor turns down the lights in the room and shines a very bright light into your eye to look for abnormal areas.

Colour fundus photography

This test may be used to show what the tumour looks like before and after a treatment, such as radiotherapy. The doctor gives you eye drops to open up your pupil. They use a special camera to take photographs of the back of your eye (known as the fundus).

PET-CT scan

This is a combination of a CT scan, which takes a series of x-rays to build up a three-dimensional picture, and a positron emission tomography (PET) scan. A PET scan uses low-dose radiation to measure the activity of cells in different parts of the body.

PET-CT scans give more detailed information about the part of the body being scanned. You may have to travel to a specialist centre to have one. You cannot eat for six hours before the scan, although you may be able to drink. A mildly radioactive substance is injected into a vein, usually in your arm. The radiation dose used is very small. You will wait for at least an hour before you have the scan. It usually takes 30 to 90 minutes. You should be able to go home after the scan.

MRI scan

This scan uses magnetism to build up a detailed picture of areas of your body. You may be given an injection of dye, into a vein, to improve the images from the scan. This test is painless and will take about 30 minutes. We have more detailed information about having an MRI scan.


Staging and grading eye melanoma

Staging

The stage of a cancer describes its size and whether it has spread. Knowing the stage helps doctors decide on the best treatment for you. There are different types of staging systems used for different cancers. Your doctor might use the TNM staging system to describe eye melanoma. TNM stands for Tumour, Node and Metastases.

TNM staging system

  • T describes the size of the tumour and whether it has grown into areas around the eye. For example, a T1 tumour is small and has not spread, while a T4 tumour is larger and has grown into areas around the eye.
  • N describes whether the cancer has spread to lymph nodes nearby. For example, N0 means that no lymph nodes are affected, while N1 means there are cancer cells in the lymph nodes. The lymph nodes are part of your body’s system to protect you from infection and disease.
  • M describes if the cancer has spread to another part of the body. This is called metastatic cancer. M0 means the cancer has not spread and M1 means the cancer has spread to distant organs, such as the liver or lungs.

Talking about staging

Your doctor or nurse will be able to give you more information about staging. They may describe the tumour as small, medium or large. They may also use the following words:

  • Early or local – This describes a cancer that has not spread outside the eye.
  • Advanced – This describes cancer that has spread to areas around the eye or to distant organs, such as the liver or lungs.

Grading

The grade of a cancer gives the doctor an idea of how quickly it may develop:

  • Low-grade – The cancer cells tend to grow slowly and look like normal cells.
  • High-grade – The cancer cells tend to grow more quickly and look very abnormal.

Doctors look at a sample of the cancer cells under a microscope to find the grade of the cancer. Your doctor does not need this information to plan your treatment for eye melanoma, and it is usually not tested unless you have a biopsy or surgery.


Treating eye melanoma

Treatment for eye melanoma may include:

  • radiotherapy
  • surgery
  • transpupillary thermotherapy (TTT)
  • cryotherapy
  • chemotherapy eye drops
  • photodynamic therapy (PDT).

You may have one or a combination of these treatments. Your treatment plan will depend on factors such as:

  • the size and position of the tumour
  • your general health
  • your eyesight.

Uveal and conjunctival melanomas are treated in slightly different ways. But the aim is to destroy the cancer cells, while doing as little damage to your eyesight as possible.

Some treatments for eye melanoma are very specialised and are only available at a few hospitals in the UK. You may have to travel to one of these hospitals for your treatment.

We have information about help you may be able to get with travel costs to and from hospital.


Radiotherapy

Radiotherapy uses high-energy rays to destroy the cancer cells, while doing as little harm as possible to normal cells. Radiotherapy may be given either from outside the body (external radiotherapy) or from inside the body (internal radiotherapy).

If you have uveal melanoma, radiotherapy may be the only treatment you need or it may be given with other treatments.

For conjunctival melanoma, you may have radiotherapy after surgery to reduce the risk of cancer coming back.

There are different types of radiotherapy:

External radiotherapy

These types of radiotherapy use high-energy rays from a machine to destroy cancer cells. This only treats the area of the body that the rays are aimed at. It does not make you radioactive.

Proton beam radiotherapy

This treatment uses proton radiation to kill cancer cells. The proton beam is aimed directly at the tumour, causing very little damage to surrounding healthy tissue.

Before the treatment, you have an operation to attach tiny metal clips to the white, outer wall of the eye. This is done under general anaesthetic. You will not be able to see the clips, but they show up on scans and this helps your team plan the treatment. You have treatment in small doses (fractions) each day for four or five days.

The clips are left in place after treatment, unless you are finding them uncomfortable. They do not cause any harm and most people cannot feel them.

Stereotactic radiotherapy

This treatment uses many small beams of radiation to target the tumour. It delivers high doses of radiotherapy to very precise areas of the body. This reduces the risk of side effects. You usually only need one session of treatment.

A number of different machines can give stereotactic radiotherapy. They include LINACs and specially designed machines such as CyberKnife™ and Gamma Knife™.

Internal radiotherapy (brachytherapy)

This treatment is given using a small radioactive disc called a plaque. It is often called plaque brachytherapy. You have an operation to attach the plaque to the wall of the eye over the tumour. You usually have a general anaesthetic for this. But sometimes, the surgeon will give you a local anaesthetic to numb the area. They will also give you drugs to help you relax before putting the plaque in.

The plaque is left in place, usually for 1 to 4 days, until the right amount of radiation has been given. After this, you have another short operation to remove the plaque.

You stay in hospital for up to a week during this treatment. While the plaque is attached to your eye, there is a small risk of radiation exposure for the people around you. 

Your doctor or nurse will give you advice about keeping yourself and others safe. You will need to stay in one room, and your visitors will only be allowed in for a short time each day. Once the plaque is taken out, you are not radioactive and you should be able to go home.

Side effects of radiotherapy

The side effects you have will depend on the type of radiotherapy and where the tumour is in the eye. Your doctor, specialist nurse or radiographer will explain what to expect during treatment and any likely side effects. You may have side effects during treatment, or months or years after treatment.

Side effects may include pain in the eye or changes to your eyesight. Often your doctor can improve these with drugs or other treatments, such as surgery.

Sometimes radiotherapy causes permanent damage to your eyesight. But this is becoming less common as new radiotherapy treatments are developed.

We have more information about the different types of radiotherapy and coping with side effects.


Surgery

This may involve removing just the tumour, a small part of the eye, or sometimes the whole eye. The type of surgery you have depends on the size and position of the tumour.

Conjunctival melanoma is often treated with surgery. The specialist surgeon is usually able to remove the tumour from the surface of the eye. You may only need a local anaesthetic to have this small operation.

If you need surgery to remove a uveal melanoma, you will have a general anaesthetic and a slightly longer operation.

The thought of having any type of surgery to your eye can be frightening, and you may have worries about how your sight will be affected. Your eye surgeon or specialist nurse will explain what to expect and answer any questions before your operation.

Rarely, some people will need a bigger operation to remove the whole eye, or the eye and nearby tissue. Your surgeon will always try to preserve your eye, if possible. They will only advise this type of surgery if it is absolutely necessary.

For many people, this suggestion can be quite shocking. You may need to talk this over several times with your doctor and specialist nurse before you make a decision. They may arrange extra support to help you cope during this difficult time, such as speaking to a counsellor or going to patient support groups.

You can also talk things over with one of our cancer support specialists on 0808 808 00 00 (Monday to Friday, 8am to 8pm).

Removing the eye (enucleation)

This operation is not common but is sometimes used to treat uveal melanoma. If the cancer is large or in a difficult position, or if you are already blind in the eye and it is painful, the surgeon may advise removing the whole eyeball.

During the operation, the surgeon removes the eyeball, puts an eye-shaped implant into your eye socket and covers it with tissue. The implant usually fills most of the space where your eyeball was. The surgeon attaches your eye muscles to the implant so that it moves like an eye.

Several weeks after the operation, you have an artificial eye (prosthesis) made. An artist makes the prosthesis to match your other eye as closely as possible. You wear the prosthesis over the implant. Because the implant moves, your prosthesis should also move quite naturally.

Removing the eye and nearby tissue (orbital exenteration)

This type of surgery is rarely needed. But it may be used to treat a large conjunctival melanoma that has spread to areas around the eye. The surgeon removes the eyeball and nearby tissue, such as the eyelids.

After the operation, you may have a facial prosthesis (false part) that covers the eye socket with false eyelids, lashes and an artificial eye. The false eye will not be able to move or blink. The prosthesis can be worn on a pair of glasses, or fixed to your face with special glue. Sometimes the prosthesis can be fitted to studs that the surgeon fixes into the bone around the eye socket.

Anyone needing this operation will be given a lot of support from their healthcare team before surgery. You may meet a counsellor or psychologist for more specialised support.


Other treatments

Other treatments are sometimes used. They may be used as the main treatment for eye melanoma, or to reduce the risk of the melanoma coming back.

Transpupillary thermotherapy (TTT)

Rarely, this can be used to treat very small uveal melanomas, or after radiotherapy to reduce the risk of the cancer coming back. The doctor gives you a local anaesthetic, then uses a type of laser beam to destroy the cancer cells by heating them. You may need more than one treatment. You can usually go home a few hours after treatment.

Cryotherapy

This can be given after surgery to reduce the risk of conjunctival melanoma coming back. The doctor freezes the area to kill any cancer cells that may have been left behind after surgery. You may have a local or a general anaesthetic for this treatment.

Chemotherapy eye drops

Sometimes you are given chemotherapy eye drops after cryotherapy for conjunctival melanoma. Your doctor or specialist nurse will explain how to use the eye drops. The drops can make your eye and eyelid red and sore. Let your doctor know if this happens so they can help.

Photodynamic therapy (PDT)

PDT may sometimes be used to treat some uveal melanomas. This treatment uses a laser, or other light sources, combined with a light-sensitive drug to destroy cancer cells.

The doctor gives you the drug as an injection into your vein. This makes cells in your body more sensitive to light. The doctor then directs a light at the eye tumour. This activates the drug and the cancer cells are destroyed. This treatment is painless, but you will be sensitive to light for several days after treatment.

We have more information about PDT.


Clinical trials

Cancer research trials are carried out to try to find new and better treatments for cancer. Trials that are carried out on patients are known as clinical trials.

Research into treatments for eye melanoma is ongoing and advances are being made. Cancer doctors use clinical trials to assess new treatments. You may be asked to take part in a clinical trial. Your doctor will discuss the treatment with you so that you have a full understanding of the trial and what it means to take part. You may decide not to take part or to withdraw from a trial at any stage. You will still receive the best standard treatment available.


Follow-up for eye melanoma

After your treatment, you will have regular check-ups. You may also have scans or x-rays. It is helpful to ask your doctor how often these scans will be. These will probably continue for several years. If you have any problems or notice any new symptoms between these times, let your doctor know as soon as possible.

Eye melanoma can sometimes spread to other parts of the body, such as the liver, lungs and bones. It is important to let your specialist know if you notice any new symptoms, wherever they are in the body, in case further treatment is needed.


Your feelings about eye melanoma

You may have many different emotions, from shock and disbelief to fear and anger. At times, these feelings can be overwhelming and hard to control. But they are natural and it is important to be able to express them.

Everyone has their own way of coping. Some people find it helpful to talk to friends or family, while others get help from people outside their situation. Sometimes it is helpful to share your experiences at a local cancer support group. Some people prefer to keep their feelings to themselves. There is no right or wrong way to cope, but help is there if you need it.

Some people with a rare cancer want to talk to someone with the same condition. Your specialist doctor may be able to put you in touch with someone. Or you may also want to contact some of the following organisations:

  • OcuMel UK – Provides information and support for people affected by ocular melanoma.
  • Melanoma Focus – Commissions and funds melanoma research. Provides support and information for patients, carers and healthcare professionals.

Our online community is a good place to meet people who are affected by cancer. It is quick and easy to join. You can talk to people in our chat rooms, blog your experiences, make friends and join support groups.

You can also call our cancer support specialists on 0808 808 00 00 for more information and support.

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