Chemotherapy for testicular cancer
You may have chemotherapy to reduce the risk of testicular cancer coming back, if the cancer has spread, or if it comes back after treatment.
On this page
- What is chemotherapy?
- Adjuvant chemotherapy
- If testicular cancer has spread or comes back during surveillance
- Intensive chemotherapy
- How chemotherapy is given
- Side effects of chemotherapy for testicular cancer
- Sex and protecting your partner
- Preventing pregnancy
- About our information
- How we can help
Chemotherapy uses anti-cancer (cytotoxic) drugs to destroy cancer cells.
The drugs most commonly used to treat testicular cancer are:
You may have chemotherapy:
- after surgery, to reduce the risk of testicular cancer coming back (adjuvant chemotherapy)
- to treat testicular cancer that has spread outside the testicle, or come back after an orchidectomy
- to treat testicular cancer that has come back after initial chemotherapy.
You may have 3 or 4 cycles of BEP if testicular cancer has:
- spread outside the testicle
- comes back during surveillance.
Bleomycin may cause breathing problems if you smoke, or already have a lung condition (see below).
If BEP does not get rid of the cancer completely, or the cancer comes back again, you usually have more intensive chemotherapy.
Depending on the stage of the cancer, some men have more intensive chemotherapy straight away.
Some drug combinations are:
High-dose chemotherapy with stem cell support (autologous stem cell transplant)
Occasionally, high-dose chemotherapy with stem cell support may be given. Stem cells produce blood cells.
The treatment destroys stem cells in the bone marrow, as well as destroying the cancer cells. Because of this, some of your stem cells are taken and stored before you have high-dose treatment. After the treatment, your stored stem cells are given back to you through a drip (infusion). This is called an autologous stem cell transplant.
High-dose chemotherapy with stem cell support allows you to have higher than usual doses of chemotherapy to treat testicular cancer. You usually have it if the cancer has not responded completely to treatment. Or you may have it if the cancer has come back after treatment. It is used to increase the chances of curing the cancer
You usually have chemotherapy drugs as an outpatient. A nurse gives you the drugs into a vein (intravenously) as an injection or a drip. They may be given through:
- a thin, flexible tube inserted into a vein in the back of your hand (cannula)
- a plastic line called a central line, which is put into a vein in your chest
- a thin tube inserted into a vein in your arm, near the bend of your elbow (PICC line).
Chemotherapy is given in cycles of treatment. A cycle usually takes 3 weeks.
If you are having BEP, you usually spend 3 to 5 days going to hospital as an outpatient. Sometimes you will stay overnight. This is followed by weekly outpatient visits to have the rest of your treatment.
Other combinations of chemotherapy drugs might mean you spend more time in hospital and have the drugs more often. Your doctor or nurse will tell you how many cycles of treatment you will have.
Chemotherapy drugs causes side effects. But there are usually ways these can be controlled. The side effects can depend on the type of chemotherapy drugs used. Your doctor or nurse will give you information about the likely side effects of your treatment.
We have more information about the side effects of chemotherapy.
Chemotherapy for testicular cancer often causes infertility during treatment and for a time after. This is usually temporary, and fertility usually recovers after treatment. But your doctor will advise you to consider storing sperm.
Macmillan is here to support you. If you would like to talk, you can do the following:
If you have sex in the first couple of days of having chemotherapy, you need to use a condom. This is to protect your partner in case there is any chemotherapy in your semen.
Cancer cannot be passed on to your partner and sex will not make the cancer worse.
Chemotherapy for testicular cancer often causes infertility during treatment and for a time after. This is usually temporary, and you should recover your fertility after treatment. But your doctor will advise you to consider storing sperm before having treatment. How quickly your sperm count recovers varies from person to person. It generally starts to recover after about 18 to 24 months following treatment. But it can take up to 5 years to recover.
You may have a low sperm count before you start cancer treatment. Treatment with chemotherapy can sometimes improve sperm production, once the sperm count has recovered after treatment.
If you are having high-dose chemotherapy have a much risk of infertility and infertility is often permanent. If you are concerned about this, you can talk to specialist.
Although treatment may affect your fertility, it is not always possible to know when this will happen. You may still be able to get someone pregnant. Your doctor will advise you not to start a pregnancy during treatment. This is because the chemotherapy drugs can temporarily damage your sperm, and possibly harm a developing baby.
It is usually best to use a ‘barrier’ method of contraception, such as a condom, while you are having treatment.
It is also important to continue using effective contraception for about a year after chemotherapy. This allows time for your sperm to recover from any damage that treatment may have caused. You can talk to your cancer doctor or nurse about this.
Below is a sample of the sources used in our testicular cancer information. If you would like more information about the sources we use, please contact us at firstname.lastname@example.org
European Association of Urology. Guidelines on Cancer. 2016. Available from: www.baus.org.uk/_userfiles/pages/files/professionals/sections/oncology/EAU2015-Testicular-Cancer.pdf (accessed August 2018)
European Society for Medical Oncology, eUpdate. Testicular Seminoma and Non-Seminoma Treatment Recommendations. June 2017. Available from: www.esmo.org/Guidelines/Genitourinary-Cancers/Testicular-Seminoma-and-Non-Seminoma/eUpdate-Treatment-Recommendation (accessed August 2018).
Scottish Intercollegiate Guidelines Network, Management of adult testicular germ cell tumours. Available from: www.sign.ac.uk/sign-124-management-of-adult-testicular-germ-cell-tumours.html (accessed August 2018).
UpToDate. Clinical manifestations, diagnosis, and staging of testicular germ cell tumors. January 2018. Available from: www.uptodate.com/contents/clinical-manifestations-diagnosis-and-staging-of-testicular-germ-cell-tumors (accessed August 2018).
This information has been written, revised and edited by Macmillan Cancer Support’s Cancer Information Development team. It has been reviewed by expert medical and health professionals and people living with cancer. It has been approved by Senior Medical Editor, Dr Jim Barber, Consultant Clinical Oncologist.
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