Phyllodes tumours are rare and most are non-cancerous (benign). They are made of a mixture of cells from connective (fibrous) tissue, and the tissue layer (epithelium) lining the breast.
The three main types of phyllodes tumour are:
- benign (non-cancerous)
- borderline tumours (between non-cancerous and cancerous)
- malignant (cancerous).
In a borderline tumour, the cells are more abnormal than in a benign tumour. But the cells are not as abnormal as those in a malignant tumour.
Treatment will cure most benign and borderline phyllodes tumours.
After treatment, the outlook for people with a malignant tumour is also usually very good.
Phyllodes tumours usually only affect one breast. But sometimes they affect both breasts. It is uncommon for phyllodes tumours to spread to other parts of the body.
We do not know the exact cause of phyllodes tumours. They can affect people of any age, but they are more common in pre-menopausal women aged between 40 and 50.
They are also more common in women who have benign breast lumps called fibroadenomas. But most women who have fibroadenomas do not develop phyllodes tumours.
The tests you have for phyllodes tumours are the same as for any type of breast cancer. You usually have scans, which include:
A mammogram is an x-ray of the breast.
- Ultrasound scan
An ultrasound scan uses sound waves to produce a picture of the breast tissue and the lymph nodes (glands) in the armpit.
- Breast biopsy
During a breast biopsy, your specialist breast cancer doctor or breast care nurse takes small samples of cells or tissue from your breast. The samples are looked at under a microscope to check for cancer cells.
Surgery is the main treatment for phyllodes tumours. It is usually the only treatment you need.
Rarely, the phyllodes tumour can be cancerous (malignant) and may have spread to other areas. In this case, you may need further treatment. Your cancer doctor will talk to you about what type of treatment you will have.
Hormonal therapy and radiotherapy, which are often used to treat breast cancer, are not used for phyllodes tumours. This is because research shows it has no effect on them.
You will usually have an operation to remove the lump as well as some surrounding healthy tissue. This is called breast-conserving surgery. It is sometimes called a lumpectomy or a wide local excision (WLE).
After your operation, a pathologist will look at the tissue that was removed under a microscope.
If there are tumour cells at the edge of the removed healthy tissue, your surgeon will usually recommend another operation. They will usually remove more tissue from the area where the tumour is. This reduces the risk of any tumour cells being left behind, and the tumour growing back.
For some women, the lump may be large in proportion to the rest of the breast. They may be advised to have the whole breast removed (mastectomy).
If you need a mastectomy, your surgeon may talk to you about options for breast reconstruction. This is when a new breast shape is formed. Sometimes, you can have breast reconstruction at the same time as mastectomy, or it may be done later.
Chemotherapy uses anti-cancer drugs (cytotoxic drugs) to destroy cancer cells.
You only have chemotherapy if the phyllodes tumour is cancerous, and has spread to another part of the body. Because phyllodes tumours do not usually spread outside the breast, it is rare to have chemotherapy as a treatment.
The drugs used to treat malignant phyllodes tumours are the same as those used to treat soft tissue sarcoma. This is because the cells that are abnormal in a phyllodes tumours are the same as the cells that are abnormal in soft tissue sarcomas.
If you do need chemotherapy, it will usually be given into a vein as an injection or a drip (infusion). You will usually have treatment over a period of about 4 to 6 months. You may have a combination of two or more chemotherapy drugs.
After your treatment you will have regular check-ups with the hospital team. They will usually ask you about your general health, examine your breasts and arrange any necessary tests.
Sometimes, phyllodes tumours can come back in the same area of breast tissue (known as a local recurrence). This risk is higher with malignant tumours.
If this does happen, your surgeon may advise that you have further surgery. This may involve another wide local excision to remove the tumour. Or you may need a mastectomy, to remove the whole breast.
You may get anxious between appointments. This is natural. It may help to get support from family, friends or a support organisation.
Macmillan is also here to support you. If you would like to talk, you can:
Below is a sample of the sources used in our phyllodes tumour information. If you would like more information about the sources we use, please contact us at firstname.lastname@example.org
Phyllodes Tumor (Cystosarcoma Phyllodes) Treatment & Management https://emedicine.medscape.com/article/188728-treatment Author: Donald R Lannin, [accessed Jan 2018]
ESMO Primary breast cancer guidelines 2015 https://www.esmo.org/guidelines/breast-cancer [accessed Jan 2018]
National Institute for Health and Care Excellence (NICE). Early and locally advanced breast cancer: diagnosis and management. July 2018.
This information has been written, revised and edited by Macmillan Cancer Support’s Cancer Information Development team. It has been reviewed by expert medical and health professionals and people living with cancer. It has been approved by Senior Medical Editor, Professor J Michael Dixon, Professor of Surgery & Consultant Surgeon.
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