You will have x-rays to check for any damage to the bones from the myeloma cells (lytic lesions). You usually have x-rays of the bones that contain bone marrow. This is called a skeletal survey. It can take about 30-45 minutes. Although x-rays are not painful, lying on a hard surface can be uncomfortable. Ask your doctor or nurse about taking painkillers before the test. Let the person doing the x-ray know if you need a painkiller during the x-rays.
Cells in contain chromosomes, which are made up of genes. Genes carry the instructions cells need to work properly. You may have a test on the cells taken from the bone marrow sample to look for changes in the chromosomes of the myeloma cells. These tests are called cytogenetic tests. A test called fluorescence in situ hybridisation (FISH) may be used to look for any cytogenetic changes. The results help the doctors understand how the myeloma may behave and to plan the most effective treatment.