Peritoneal biopsy
What is a peritoneal biopsy?
During a biopsy, a small piece of tissue is removed so that it can be looked at under a microscope. Your doctor may suggest a biopsy of the peritoneum (lining that covers the organs in the tummy) to help diagnose peritoneal mesothelioma. It can be done in 2 ways.
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Laparoscopy (keyhole surgery)
A laparoscopy allows the doctor to look at other areas in your tummy (abdomen) and take more biopsies if needed. It is done under general anaesthetic. Your doctor will make a small cut in the tummy wall. They will put a thin tube with a light and camera at the end (laparoscope) into your tummy. They can then take a small biopsy of the peritoneum. They will also check nearby organs to see if the mesothelioma has spread.
CT or ultrasound guided biopsy
The doctor will give you a local anaesthetic to numb the area. They use an ultrasound or a CT scan to help guide them to the right place. They pass a special type of needle through your skin into the area they want to take a biopsy from. The needle has a tip that can cut out a small sample of tissue.
After the biopsy
Having a biopsy can be uncomfortable but should not be painful. If you have any pain during or after the procedure, tell your doctor or nurse.
After the doctor has taken the biopsy, they will send it to the laboratory. A doctor who looks at cells or body tissue under a microscope to diagnose cancer (pathologist) will look at the biopsy.
Sometimes, even after taking a biopsy, the doctors may not be sure of the diagnosis. This is because it can be difficult to find the difference between mesothelioma and some other cancers and illnesses.
If this happens, the samples may be sent to specialist laboratories to confirm the diagnosis. You may need to have a test done again, or you may be referred to another hospital for a second opinion.
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About our information
This information has been written, revised and edited by Macmillan Cancer Support’s Cancer Information Development team. It has been reviewed by expert medical and health professionals and people living with cancer.
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References
Below is a sample of the sources used in our mesothelioma cancer information. If you would like more information about the sources we use, please contact us at informationproductionteam@macmillan.org.uk
Kusamura S, Kepenekian V, Villeneuve L, Lurvink RJ, Govaerts K, De Hingh IHJT, Moran BJ, Van der Speeten K, Deraco M, Glehen O; PSOGI. Peritoneal mesothelioma: PSOGI/EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Eur J Surg Oncol. 2021 Vol, 47(1) pp6-59. [accessed April 2024].
Popat, S., Baas P., Faivre-Finn, C., Girard, N., Nicholson, A., Nowak, A., Opitz, I., Scherpereel, A, and Reck, M. 2021. ESMO Pleural mesothelioma guidelines. Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Available from: https://www.annalsofoncology.org/action/showPdf [accessed April 2024].
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