Anastrozole

Anastrozole is a hormonal therapy drug used to treat breast cancer and sometimes other cancers. It is best to read this information with our general information about hormonal therapies and the type of cancer you have.

Anastrozole is usually given as tablets. You usually have it as an outpatient. Your cancer doctor, nurse or pharmacist will tell you how often you will have it.

Like all cancer drugs, anastrozole can cause side effects. Some of the side effects can be serious, so it is important to read the detailed information below.

Your healthcare team can give you advice on how to manage any side effects. Tell your doctor or nurse straight away if you feel unwell or have severe side effects, including any we do not mention here.

Rarely, side effects may be life-threatening. Your cancer doctor or nurse can explain the risk of these side effects to you.

If you need medical attention for any reason other than cancer, always tell the healthcare staff that you are having this treatment.

What is anastrozole?

Anastrozole is a hormonal therapy drug used to treat breast cancer and sometimes other cancers. It can be given alone or with other types of treatment. It is best to read this information with our general information about hormonal therapies and the type of cancer you have.

Your doctor will talk to you about this treatment and its possible side effects before you agree (consent) to have treatment.


How anastrozole works

Hormones are chemicals that our bodies make. Hormones act as messengers and help control how cells and organs work. Hormonal therapies are drugs that change the way hormones are made or how they work in the body.

Many breast cancers rely on the hormone oestrogen to grow. This type of breast cancer is called oestrogen receptor-positive (ER-positive) breast cancer.

After a woman goes through the menopause, oestrogen is no longer made in the ovaries. Instead, it is made in the fatty tissues of the body. This happens when an enzyme (a type of protein) called aromatase changes other hormones into oestrogen.

Anastrozole is a type of drug called an aromatase inhibitor. It blocks (inhibits) the activity of aromatase and reduces the amount of oestrogen in the body.


When anastrozole is given

Anastrozole is used to treat breast cancer in women. You may have it to reduce the risk of breast cancer coming back.

It is often used in women who have been through the menopause. But it may also be given to women who have not had the menopause. In this situation, you usually have anastrozole with a drug that stops the ovaries making oestrogen, or with surgery to remove the ovaries.

It may also be given along with the targeted therapy drugs ribociclib and palbociclib when breast cancer has spread to other parts of the body (secondary breast cancer).

Anastrozole is also sometimes used to treat breast cancer in men.

Your doctor or nurse will explain why you are having anastrozole and how long you will take it for.


Taking your anastrozole tablets

Anastrozole comes as tablets you can take at home. You may have anastrozole on its own, or with other drugs. Your nurse or doctor will talk to you about your treatment plan.

Always take the tablets exactly as explained. This is important to make sure they work as well as possible for you. Make sure you:

  • swallow them whole with a glass of water
  • do not chew, open or crush the tablets
  • take them at the same time every day.

If you forget to take the tablets, you should take the missed dose as soon as possible within the same day. If a full day has passed, let your doctor or nurse know. Do not take a double dose unless your doctor tells you to.

Other things to remember about your tablets:

  • Keep them in the original package and at room temperature, away from heat and direct sunlight.
  • Keep them safe and out of reach of children.
  • If you are sick just after taking the tablets, contact your healthcare team. Do not take another dose.
  • Get a new prescription before you run out of tablets, and make sure you have plenty for holidays.
  • If your treatment is stopped, return any unused tablets to the pharmacist.

Your nurse or pharmacist may also give you other medicines to take home. Take all your medicines exactly as they have been explained to you. Do not stop taking any of your medicines unless your doctor tells you to.


About side effects

We explain the most common side effects of this treatment here. We also include some less common side effects.

You may get some of the side effects we mention, but you are unlikely to get all of them. If you are also having treatment with other cancer drugs, you may have some side effects that we haven’t listed here. Always tell your doctor, nurse or pharmacist about any side effects you have.

Your doctor can give you drugs to help control some side effects. It is important to take them exactly as your nurse or pharmacist explains. This means they will be more likely to work for you. Your nurse will give you advice about managing your side effects. After your treatment is over, most side effects start to improve.

Serious and life-threatening side effects

Some cancer treatments can cause severe side effects. Rarely, these may be life-threatening. Your cancer doctor or nurse can explain the risk of these side effects to you.

Contact the hospital

Your nurse will give you telephone numbers for the hospital. If you feel unwell or need advice, you can call them at any time of the day or night. Save these numbers in your phone or keep them somewhere safe.

More information

We cannot list every side effect for this treatment. There are some rare side effects that are not listed. You can visit the electronic Medicines Compendium (eMC) for more detailed information.


Common side effects

Allergic reaction

Some people have an allergic reaction while having this treatment. Signs of a reaction can include:

  • feeling hot or flushed
  • a skin rash
  • itching
  • shivering
  • feeling dizzy
  • a headache
  • feeling breathless.

If you feel unwell or have any of these signs, stop taking your treatment and tell a doctor or nurse straight away.

Hot flushes and sweats

These are common. During a flush, your neck and face may feel warm and look red. Flushes can last for a few seconds or for up to 10 minutes. You may have sweats then feel cold and clammy. Some people feel anxious or irritable during a hot flush.

There are things you can do to try to reduce flushes:

  • Wear clothes made from natural fabrics, such as cotton.
  • Dress in layers of clothes that you can remove as needed.
  • Use cotton sheets and have layers of bedding.
  • Keep the room temperature cool or use a fan.
  • Have cold drinks rather than hot ones. Try to avoid drinks with caffeine in them.

You may have fewer hot flushes and sweats as your body adjusts to hormonal treatment. Or your doctor can prescribe drugs to help. Some people continue to have flushes and sweats, but they usually stop a few months after treatment finishes.

Women coping with hot flushes can read more in our information about managing menopausal symptoms.

Muscle or joint pain

You may get pain in your muscles or joints. If this happens, tell your doctor so they can give you painkillers. Being physically active and keeping to a healthy weight may help with the pain. It will also keep your joints flexible. Let your doctor or nurse know if it does not get better.

Tiredness

Feeling tired is a common side effect. Try to pace yourself and plan your day so you have time to rest. Gentle exercise, like short walks, can give you more energy. If you feel sleepy, do not drive or operate machinery.

Feeling sick (nausea) or being sick (vomiting)

Any sickness is usually mild. But let your doctor or nurse know if this happens. Try taking your anastrozole tablets with food or at night.

Loss of appetite

Try to eat small, frequent meals or snacks instead of 3 meals a day. This may be helpful if you have lost your appetite or find it difficult to eat big meals.

Changes to your taste

You may get a bitter or metal taste in your mouth. Sucking sugar-free sweets may help with this. Some foods may taste different or have no taste. Try different foods to find out what tastes best to you. Taste changes usually get better after treatment finishes. Your nurse can give you more advice.

Headaches

This treatment may cause headaches. If this happens, tell your doctor or nurse. They can give you painkillers.

Skin changes

This treatment may affect your skin. Your doctor or nurse can tell you what to expect. If your skin feels dry, try using an unperfumed moisturising cream every day. The treatment may cause a rash, which may be itchy.

Always tell your doctor or nurse about any skin changes. They can give you advice and may give you creams or medicines to help. Any changes to your skin are usually temporary and improve when treatment finishes.

Hair thinning

Your hair may become thinner while taking this treatment. This is usually mild. Ask your nurse for advice if this is a problem for you.

Vaginal bleeding or dryness

This treatment can cause vaginal bleeding or dryness. Bleeding may happen when you start taking anastrozole or change to it from another treatment. If bleeding continues for more than a few days, tell your doctor or nurse.

You can use non-hormonal creams, gels or lubricants to help with vaginal dryness and any discomfort during sex. You can buy these from a chemist, or your doctor can prescribe them.

Pain, numbness and tingling in hand and fingers

These symptoms may be because of carpal tunnel syndrome, which is caused by pressure on a nerve in the wrist. It is more common in people taking anastrozole. Tell your doctor if you have these symptoms.

Raised cholesterol level

This treatment can raise the level of cholesterol (a fatty substance) in the blood. Your doctor may check this with a blood test. Your doctor may give you medicines to control your cholesterol levels.

Effects on the liver

This treatment can affect how your liver works. This usually goes back to normal after treatment. You will have blood tests to check how well your liver is working during your treatment.

Bone thinning (osteoporosis)

Taking this treatment for several months or more can cause bone thinning. This is called osteoporosis. This can increase your risk of a broken bone (fracture). You may have bone density scans to check your bone health before and during treatment.

Keeping physically active and eating a healthy diet helps look after your bones. Your doctor may prescribe drugs called bisphosphonates to help protect your bones. They may also advise you to take calcium and vitamin D supplements.

Coping with fatigue

Denton describes how he coped with fatigue (tiredness) during his treatment for prostate cancer.

About our cancer information videos

Coping with fatigue

Denton describes how he coped with fatigue (tiredness) during his treatment for prostate cancer.

About our cancer information videos


Other information

Blood clot risk

Cancer and some cancer treatments can increase the risk of a blood clot. Symptoms of a blood clot include:

  • pain, redness or swelling in a leg or arm
  • breathlessness
  • chest pain. 

If you have any of these symptoms, contact a doctor straight away. 

A blood clot is serious, but can be treated with drugs that thin the blood. Your doctor or nurse can give you more information.

Fertility

Some cancer drugs can affect whether you can get pregnant or father a child. If you are worried about this, it is important to talk with your doctor before you start treatment.

Contraception

Your doctor will advise you not to get pregnant or father a child while having this treatment and for some time afterwards. The drugs may harm the developing baby. It is important to use effective contraception.

Breastfeeding

Women are advised not to breastfeed while having this treatment and for some time afterwards. This is because the drugs could be passed to the baby through breast milk.

Other medicines

Some medicines can affect the hormonal treatment or be harmful when you are having it. This includes medicines you can buy in a shop or chemist. Tell your cancer doctor about any drugs you are taking, including vitamins, herbal drugs and complementary therapies.

Medical and dental treatment

If you need medical treatment for any reason other than cancer, always tell the doctors and nurses that you are having cancer treatment. Give them the contact details for your cancer doctor so they can ask for advice.

If you think you need dental treatment, talk to your cancer doctor or nurse. Always tell your dentist you are having cancer treatment.

Lactose

Anastrozole tablets contain a type of sugar called lactose. If you have been told by a doctor that you cannot digest lactose (lactose intolerant) or other sugars, talk to your doctor before taking this drug.