Targeted therapies for lung cancer
Targeted therapy and immunotherapy drugs are usually used to treat non-small cell lung cancer (NSCLC) that has spread outside the lung or to other parts of the body. They are not commonly used for small-cell lung cancer (SCLC).
To find out the right treatment for you, the cancer cells taken during a biopsy or surgery are tested. Tests look for gene mutations (changes) and whether the cancer cell is making certain proteins. This is called molecular testing. Tests can also be done on blood taken with a blood test, but this is rare.
The results help your doctor to decide which treatment is the most suitable for you. The drug you have may also depend on whether you have squamous or adenocarcinoma NSCLC.
Your cancer doctor or specialist nurse will tell you which drugs are suitable for you. You may have some of these drugs as part of a clinical trial.
You may have one of these drugs if tests find an abnormal change in the epidermal growth factor receptor (EGFR) gene. It makes an abnormal form of EGFR protein, which can make the cancer cells grow. This is sometimes called EGFR-positive lung cancer.
The following drugs block signals from EGFR to the cancer cells which stops them growing:
- gefitinib (Iressa®)
- afatanib (Giotrif®)
- erlotinib (Tarceva®)
- dacomitinib (Vizimpro®)
- osimertinib (Tagrisso®).
You take them as tablets. Your doctor or nurse can give you more information. You can read more about the individual drugs in our treatments and drugs A-Z.
If you have been told you have a type of NSCLC called EGFR+ lung cancer, you can find information and support at EGFR Positive UK.
A small number of people (1 in 25) with (NSCLC) have a change in a gene called anaplastic lymphoma kinase (ALK). It makes an abnormal protein that can make the cancer cells grow. This is sometimes called ALK-positive NSCLC. If you have this, your doctor may give you one of these drugs:
You take these drugs as capsules.
If your treatment stops working your doctor may advise another ALK drug, such as:
- ceritinib (Zykadia®) if you have not had it
- brigatinib (Alunbrig®)
If you have been told you have a rare type of NSCLC called ALK+ lung cancer, you can find information and support at ALK Positive UK.
Nintedanib (Vargatef®) is a targeted therapy drug used to treat adenocarcinoma type NSCLC. It may be given if the cancer comes back, or has spread after you have already had chemotherapy. Nintedanib is given with the chemotherapy drug docetaxel.
You take it as a capsule. Your doctor or nurse can give you more information. We have more information about these drugs, and their possible side effects.
Macmillan is also here to support you. If you would like to talk, you can:
Below is a sample of the sources used in our lung cancer information. If you would like more information about the sources we use, please contact us at firstname.lastname@example.org
National Institute for Health and Care Excellence (NICE). Lung cancer – Diagnosis and management. Clinical guideline 2019.
Metastatic non-small cell lung cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. 2018.
European Society for Medical Oncology (ESMO). Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO clinical practice guidelines for diagnosis, treatment and follow-up. 2017.
This information has been written, revised and edited by Macmillan Cancer Support’s Cancer Information Development team. It has been reviewed by expert medical and health professionals and people living with cancer. It has been approved by Senior Medical Editor, Dr David Gilligan, Consultant Clinical Oncologist.
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