What is cervical intra-epithelial neoplasia (CIN)?

Cervical intra-epithelial neoplasia (CIN) is a term that describes changes in the squamous cells of the cervix.

CIN is not cancer, but you may need treatment to stop cervical cancer developing. You may hear doctors call CIN a pre-cancerous condition.

You might not need treatment for CIN. If you do need treatment, it’s usually simple and very successful.

Causes of CIN

We don’t know all the causes of CIN. But they include human papilloma virus (HPV) and smoking.


Women who smoke are almost twice as likely to develop CIN as non-smokers.

Symptoms of CIN and HPV

CIN and HPV on the cervix have no symptoms. It’s essential for women to have regular cervical screening tests to find any early cell changes.

The more people I spoke to about it, the more common I suppose it was. Everybody I spoke to had had abnormalities at some time.

Melanie, affected by cancer

Back to Pre-cancerous conditions

Breast calcifications

Breast calcifications are usually harmless. These small deposits of calcium are most likely to be found during a mammogram.

Lobular carcinoma in situ (LCIS)

Women with Lobular carcinoma in situ (LCIS) should have regular breast screening. LCIS is not a cancer, but indicates a risk of cancer in later life.


MGUS (mono gammopathy of unknown significance) is a non-cancerous condition. It does not usually cause any symptoms but a small number of people are more likely to develop cancer.

Barrett's oesophagus

Barrett's oesophagus is a condition that can sometimes develop into cancer of the lower oesophagus.

Bowen's disease

Bowen’s disease is a skin condition. Rarely, Bowen’s disease that isn’t treated may develop into skin cancer.