Causes and risk factors of kidney cancer
What are risk factors?
The causes of kidney cancer are unknown, But there are certain things that can affect the chances of developing kidney cancer. These are called risk factors.
Having a risk factor does not mean you will definitely get kidney cancer. And if you do not have any known risk factors, you may still develop kidney cancer.
Cancer is not infectious, and you cannot pass it on to other people.
Sex
Kidney cancer is more common in men than in women.
Age
The risk of kidney cancer increases with age. Most people who get kidney cancer are aged over 60. But it can affect people younger than this.
Smoking
Smoking increases the risk of kidney cancer. The more you smoke, the greater your risk.
Risk goes down when you stop smoking. After 10 years, it returns to the same risk as a non-smoker.
Being overweight
Studies show that obesity (being significantly overweight) increases the risk of kidney cancer.
High blood pressure
Having high blood pressure (hypertension) may slightly increase the risk of kidney cancer. But most people with high blood pressure do not develop kidney cancer.
Kidney disease
People with advanced kidney disease have a higher risk of kidney cancer. The risk is greatest for people who need treatment that does the work of the kidneys (dialysis).
Waste products from the blood can sometimes cause hard stones to form in the kidneys. Men with these kidney stones have a higher risk of kidney cancer.
Diabetes
Family history
Most people who get kidney cancer do not have a family history of it. But your risk may be higher than average if a close relative has had kidney cancer.
Close relatives are your parents, brothers, sisters or children. Fewer than 1 in 20 kidney cancers (5%) are thought to be inherited.
Genetic risk
Some rare genetic conditions can increase the risk of developing kidney cancer. These include:
- von Hippel-Lindau disease
- hereditary papillary RCC (HPRCC)
- Birt-Hogg-Dubé syndrome (BHD)
- tuberous sclerosis
- sickle cell disease or sickle cell trait.
Kidney cancers caused by an inherited gene change (mutation) are more likely to happen at a younger age. They may cause several tumours and can affect both kidneys.
People who have had thyroid cancer have an increased risk of kidney cancer. This may be because of genetic mutations that are linked to both cancers.
Exposure to certain materials at work
An increased risk of kidney cancer has been linked to working with blast furnaces or coke ovens in the steel and coal industries. Exposure to certain materials, such as cadmium, lead or asbestos, may also increase risk.
Date reviewed
This content is currently being reviewed. New information will be coming soon.
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