Docetaxel (Taxotere®) and carboplatin chemotherapy
This information is about a chemotherapy treatment for lung cancer called docetaxel and carboplatin. It may also be used to treat other types of cancer.
The drugs that are used
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The treatment involves the two drugs: docetaxel, which is also called Taxotere®, and carboplatin.
How treatment is given
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Your chemotherapy treatment will usually be given to you as a day patient, or occasionally you may need to stay in hospital overnight. Before you start treatment you will have a blood test, either on the same day or a few days beforehand. You will also be seen by a doctor, specialist nurse or pharmacist. You'll also have tests to check how well your kidneys are working, as the chemotherapy can affect them. These may include collecting your urine for 24 hours or having a specific blood test known as an EDTA test.
If the results of your tests are normal, the pharmacy will prepare your chemotherapy drugs. This may take a couple of hours.
Before you start the chemotherapy you'll be asked to take steroid tablets. These help prevent an allergic reaction to the docetaxel and can also help prevent sickness. It's very important to take these tablets. If you haven't taken them, tell your doctor or nurse before you start your chemotherapy.
The nurse will insert a thin, flexible tube (cannula) into a vein in your hand or arm. You may find this uncomfortable or a little painful, but it shouldn't take long. Some people have their chemotherapy given through a thin, plastic tube inserted under the skin and into a vein near the collarbone (central line) or passed through a vein in their arm (a PICC line). Your doctor or nurse will explain more about this to you.
You'll be given anti-sickness (anti-emetic) drugs, usually by injection through the cannula, central line or PICC line. Some anti-sickness drugs can be given as tablets.
You'll be given docetaxel and carboplatin (both are colourless fluids) as drips (infusions). They are given separately and usually take about an hour each.
If you're being treated as a day patient you can go home after you've been given the drugs. Before you go, a nurse will remove your cannula. If you have a central or PICC line it will usually stay in place, ready for the next cycle of your chemotherapy. You will be shown how to look after the line.
You'll be given a supply of anti-sickness tablets to take home with you, as well as the steroids. It is important to take these as directed even if you're not feeling sick. This is because some anti-sickness drugs are much better at preventing sickness than stopping it once it starts.
How often treatment is given
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Your doctor may use the word 'regimen' (eg the docetaxel and carboplatin regimen) when talking about your chemotherapy. This means the whole plan or schedule of your particular chemotherapy treatment.
After you have been given docetaxel and carboplatin (as described above) you'll have a rest period with no chemotherapy for the next three weeks. This completes what is called a cycle of your treatment. Each cycle lasts for 21 days (three weeks).
After the rest period the same treatment is repeated, which begins the next cycle of your chemotherapy. Usually up to 4–6 cycles are given over four months.
Each person’s reaction to chemotherapy is different. Some people have very few side effects while others may experience more. The side effects described here won't affect everyone who has treatment with docetaxel and carboplatin.
We have outlined the most common side effects but haven't included those that are rare and therefore unlikely to affect you. If you notice any effects that aren't listed here, discuss them with your doctor, chemotherapy nurse or pharmacist.
Risk of infection
Docetaxel and carboplatin can reduce the number of white blood cells, which help fight infection. White blood cells are produced by the bone marrow. If the number of your white blood cells is low you'll be more prone to infections.
A low white blood cell count is called neutropenia. This can begin 5–7 days after treatment and your resistance to infection usually reaches its lowest point 7–10 days after chemotherapy. The number of white blood cells in your blood then increases steadily and usually returns to normal before your next cycle of chemotherapy is due.
Contact your doctor or the hospital straight away if:
your temperature goes above 38°C (100.4°F)
you suddenly feel unwell, even with a normal temperature.
You'll have a blood test before having more chemotherapy to check the number of white blood cells in your blood. Occasionally your treatment might need to be delayed if the number of blood cells (blood count) is still low.
Bruising and bleeding
Docetaxel and carboplatin can reduce the production of platelets, which help the blood to clot. Tell your doctor if you have any unexplained bruising or bleeding, such as nosebleeds, bleeding gums, blood spots or rashes on the skin. You can have a platelet transfusion if your platelet count is low.
Docetaxel and carboplatin can reduce the number of red blood cells, which carry oxygen around the body. A low red blood cell count is called anaemia. This may make you feel tired and breathless. Tell your doctor or nurse if you have these symptoms. You may need to have a blood transfusion if the number of red blood cells becomes too low.
Feeling sick (nausea) and being sick (vomiting)
Your doctor can prescribe very effective anti-sickness (anti-emetic) drugs to prevent, or greatly reduce, nausea or vomiting. If the sickness isn't controlled, or if it continues, tell your doctor; they can prescribe other anti-sickness drugs that may be more effective.
Some anti-sickness drugs can cause constipation. Let your doctor or nurse know if this is a problem.
Feeling tired is a common side effect of chemotherapy, especially towards the end of treatment and for some weeks after it’s over. It’s important to try to pace yourself and get as much rest as you need. Try to balance this with taking some gentle exercise, such as short walks, which will help. If tiredness is making you feel sleepy, don’t drive or operate machinery.
This usually starts 2–3 weeks after the first dose of docetaxel, although it may occur earlier. Hair usually falls out completely. You may also have thinning and loss of eyelashes, eyebrows and other body hair. This is usually temporary and your hair will almost always start to grow again once the treatment has finished. Your hair may grow back straighter, curlier, finer, or a slightly different colour than it was before treatment. Your nurse can give you advice about coping with hair loss.
Scalp cooling is a method of reducing hair loss that may be helpful for some people. You can ask your doctor or nurse if it is available at your hospital.
Your mouth may become sore or dry, or you may notice small ulcers during this treatment. Drinking plenty of fluids, and cleaning your teeth regularly and gently with a soft toothbrush, can help reduce the risk of this happening. Some people find sucking on ice soothing. Tell your nurse or doctor if you have any of these problems, as they can prescribe mouthwashes and medicine to prevent or clear mouth infections.
You may notice that food tastes different. Normal taste usually comes back after treatment finishes. A dietitian or specialist nurse at your hospital can give you advice about ways of coping with this side effect.
Docetaxel and carboplatin can cause diarrhoea. This can usually be easily controlled with medicine, but tell your doctor if it is severe or continues. It's important to drink plenty of fluids if you have diarrhoea.
A skin rash can sometimes occur while you are having treatment with docetaxel. It’s important to let your doctor know if this happens. Your doctor can prescribe medicine to help with this.
Sometimes areas of skin that have been treated with radiotherapy may become red and sore. Tell your doctor if this happens.
Soreness and redness of the palms of the hands and soles of the feet
This is sometimes known as palmar plantar or hand-foot syndrome. It can happen when docetaxel is given. It is usually temporary and improves when the treatment is finished.
Your doctor may prescribe creams or a vitamin called pyridoxine (vitamin B6), which some people find helpful. It can also help to keep your hands and feet cool and to avoid tight-fitting clothing, such as socks, shoes and gloves.
Some people can have an allergic reaction to docetaxel while it’s being given. Signs of this can include skin rashes and itching, a high temperature, shivering, dizziness, a headache and breathlessness.
Usually you'll be given steroid tablets to take at home the day before treatment to reduce the chance of this happening. It’s important to take the steroid tablets as you've been directed. Instead of steroid tablets, you may be given a steroid by injection into a vein (intravenously) 30–60 minutes before the docetaxel.
Other drugs, such as antihistamines, may also be injected into a vein before your treatment to prevent an allergic reaction.
You'll be closely monitored for any signs of an allergic reaction during the treatment. Tell your doctor or nurse if you have any of these symptoms. If you do have a reaction, it can be treated quickly.
Less common side effects
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Pain along the vein
Docetaxel can cause pain along the vein that's used to give you your chemotherapy. If you feel any pain, tell your doctor or nurse straight away so they can check the infusion site. They may slow the infusion down to reduce pain.
Numbness or tingling in hands or feet
This is due to the effect of docetaxel on the nerves and is known as peripheral neuropathy. You may also notice that you have difficulty doing up buttons or similar fiddly tasks.
Tell your doctor if you notice any numbness or tingling in your hands or feet. It is important to report your symptoms to your doctor as they may be controlled by slightly lowering the dose of the drug.
This side effect usually improves slowly, a few months after the treatment has finished. Sometimes symptoms can persist, talk to your doctor if this happens.
The colour of your nails may change. They may become darker and white lines may appear on them. These usually grow out over several months once the treatment has finished. Some people have pain in the nail bed at the base of the nail but this is rare.
Increased production of tears
This may be caused by docetaxel and is temporary. You may also notice that your eyes become sore and inflamed (conjunctivitis). Let your doctor know so they can prescribe soothing eye drops if necessary.
Pain in joints or muscles
This may be caused by docetaxel. It is important to tell your doctor about this so that they can prescribe painkillers to help.
Loss of appetite
Some people lose their appetite while they’re having chemotherapy. This can be mild and may only last a few days. If it doesn’t improve you can ask to see a dietitian or specialist nurse at your hospital. They can give you advice on improving your appetite and keeping to a healthy weight.
Always let your doctor or nurse know about any side effects you have. There are usually ways in which they can be controlled or improved.
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Risk of developing a blood clot
Cancer can increase the risk of developing a blood clot (thrombosis), and chemotherapy may increase this risk further.
A blood clot may cause symptoms such as pain, redness and swelling in a leg, or breathlessness and chest pain. Blood clots can be very serious so it’s important to tell your doctor straight away if you notice any of these symptoms. Most clots can be treated with drugs that thin the blood. The doctor or nurse can give you more information.
Some medicines, including those that you can buy in a shop or chemist, can be harmful to take when you are having chemotherapy. Tell your doctor about any medicines you are taking, including over-the-counter drugs, complementary therapies and herbal drugs.
Your ability to become pregnant or father a child may be affected by having this treatment. It's important to discuss fertility with your doctor before starting treatment.
It's not advisable to become pregnant or father a child while taking docetaxel and carboplatin, as it may harm the developing baby. It's important to use effective contraception while taking these drugs and for at least a few months afterwards. You can discuss this with your doctor or nurse.
It’s not known whether chemotherapy drugs can be present in semen or vaginal fluids. To protect your partner, it’s safest to either avoid sex or use a barrier form of contraception for about 48 hours after chemotherapy.
Loss of periods in women
Because of the effect of chemotherapy on the ovaries, women may find that their periods become irregular and they may eventually stop. In some women this may be temporary, but for others it will be permanent. This will result in menopausal symptoms such as hot flushes, sweats and vaginal dryness.
If you’re admitted to hospital for a reason not related to the cancer, it’s important to tell the doctors and nurses looking after you that you're having chemotherapy treatment. You should tell them the name of your cancer specialist so they can ask for advice.
It’s a good idea to know who you should contact if you have any problems or troublesome side effects when you’re at home. Your chemotherapy nurse or doctor will give you details of who to contact for advice. This should include ‘out-of hours’ contact details if you need to call someone at evenings, overnight or at the weekend.
This section based upon our docetaxel and carboplatin chemotherapy fact sheet, which has been compiled using information from a number of reliable sources including:
Sweetman, et al. Martindale: The Complete Drug Reference. 37th edition. 2011. Pharmaceutical Press.
British National Formulary. 62nd edition. 2011. British Medical Association and Royal Pharmaceutical Society of Great Britain.
electronic Medicines Compendium (eMC). (accessed October 2011).
Perry MC. The Chemotherapy Source Book. 4th edition. 2007. Lippincott Williams and Wilkins.