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Macmillan and Cancerbackup merged in 2008. Together we provide free, high quality information for people affected by cancer through our publications, website and phone service. Find out more|.
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This information is about a rare type of sarcoma of the bone called osteosarcoma, sometimes also called osteogenic sarcoma. It should ideally be read with our general information about primary bone cancer.
We also have information on osteosarcoma in children|.
Primary bone cancers are cancers that start in the bone. They are rare, with only about 400 people diagnosed each year in the UK. There are several different types of bone cancer.
Osteosarcoma is the most common type of primary bone cancer and usually develops in growing bones. Although it can occur at any age, osteosarcoma is most commonly found in teenagers| and young adults, and is slightly more common in males. Any bone in the body can be affected, but the most common sites are the arms or legs, particularly around the knee joint.
There are several different types of osteosarcoma. Most osteosarcomas occur in the centre of the bone. There are also rare subtypes, such as parosteal, periosteal, telangiectatic and small cell osteosarcoma.
The exact causes of primary bone cancer are unknown. It is thought to be related to periods of rapid bone growth, such as adolescence. Adults who have a bone condition known as Paget’s disease or who have been exposed to high doses of radiotherapy| may have a slightly increased risk of developing bone cancer. Rarely, some bone cancers may occur in people from families where there is an inherited faulty gene| that increases the risk of developing particular types of cancer.
Pain is the most common symptom of bone cancer. However, symptoms may vary depending on the location and size of the cancer. Tumours that occur in or near joints may cause swelling or tenderness in the affected area. Primary bone cancer is sometimes discovered when a bone that has been weakened by cancer breaks after the person has had a minor fall or accident.
The symptoms described above can be caused by many things other than cancer. However, any persistent bone pain, particularly at night, should be checked by your doctor.
Usually you begin by seeing your family doctor (GP), who will examine you and may arrange any necessary tests or x-rays. Your GP will probably refer you to a specialist surgeon (called an orthopaedic surgeon) who can carry out other investigations and decide if you need to be referred to a specialist hospital or bone tumour centre for further tests. Many of the specific tests for diagnosing bone tumours, such as biopsies, require experience and specialist techniques.
The doctor at the hospital will take your full medical history before doing a physical examination. This will include an examination of the painful bone to check for any swelling or tenderness. You will probably have a blood test done to check your general health.
A variety of tests and investigations may be needed to diagnose an osteosarcoma. An x-ray of the painful part of the bone will usually identify a tumour, although sometimes they can be difficult to see. A small piece of the tumour will be removed and looked at under a microscope (biopsy). This is done during a small operation, under a general anaesthetic.
Bone x-ray This involves the use of energy beams to build up a picture of the bone.
CT (computerised tomography) scan A CT scan takes a series of x-rays that builds up a three-dimensional picture of the inside of the body. The scan is painless and takes from 10 to 30 minutes. CT scans use a small amount of radiation, which is very unlikely to harm you and will not harm anyone you come into contact with. You will be asked not to eat or drink for at least four hours before the scan.
You may be given a drink or an injection of dye that allows particular areas to be seen more clearly. For a few minutes this may make you feel hot all over. If you are allergic to iodine or have asthma, you could have a more serious reaction to the injection, so it is important to let your doctor know beforehand.
Most people are able to go home as soon as their scan is over.
MRI scan (magnetic resonance imaging) This test is similar to a CT scan, but uses magnetism instead of x-rays to build up cross-sectional pictures of your body. During the test you will be asked to lie very still on a couch inside a large metal cylinder that is open at both ends. The whole test may take up to an hour. It can be slightly uncomfortable and some people feel a bit claustrophobic during the scan. It is very noisy, but you will be given earplugs or headphones to wear. You can usually take someone with you into the room to keep you company. A two-way intercom allows you to talk with the people controlling the scanner. If you have any metal implants (such as surgical clips, pacemakers, metal in the eye from previous accidents or trauma) it will not be possible for you to have this test.
Bone scan This is a more sensitive test than the simple x-ray and shows up any abnormal areas of bone more clearly. For this test, a small amount of a mildly radioactive substance is injected into a vein, usually in your arm. Abnormal bone absorbs more radioactivity than normal bone so these areas are highlighted and picked up by the scanner as 'hot spots'.
Needle biopsy For this test a small sample of the tumour is taken from the affected bone. The doctor then examines the sample under a microscope to identify the exact type of tumour that you may have.
Open biopsy This type of biopsy is not often used, as the needle biopsy is much quicker and simpler. In an open biopsy a small piece of bone is removed during a minor operation while you are under a general anaesthetic. It may be necessary to do this if a needle biopsy can't be done or doesn't give a clear diagnosis.
Chest x-ray In osteosarcoma, the most common place for the cancer to spread to is the lungs. A chest x-ray is usually done to check for this.
Grading refers to the appearance of the cancer cells under the microscope and gives an idea of how quickly the cancer may develop. Low-grade means that the cancer cells look very like normal cells and they are usually slowly growing and are less likely to spread. In high-grade tumours the cells look very abnormal and are likely to grow more quickly and are more likely to spread.
Most osteosarcomas are high grade, but a type known as a parosteal osteosarcoma is usually low-grade. A further subtype (periosteal osteosarcoma) is usually treated as though it was high-grade.
The stage of a cancer is a term used to describe its size and whether it has spread beyond its original site. Knowing the particular type and the stage of the cancer helps the doctors to decide on the most appropriate treatment.
Most people are grouped depending on whether cancer is found in only one part of the body, which is known as localised disease or whether the cancer has spread from one part of the body to another (metastatic disease).
If the cancer comes back after initial treatment, this is known as recurrent or relapsed cancer.
The type of treatment you are given will depend on a number of things, including the position and size of the cancer, whether it has spread, the grade of the cancer and your general health.
As osteosarcomas are very rare they are usually treated at specialist hospitals by a team of doctors and other health professionals. This means that you may have to travel some distance to have your treatment.
Most people with an osteosarcoma will need to have a combination of different treatments. The treatments that may be used are surgery, chemotherapy and radiotherapy.
Surgery is a very important part of treatment and is used to remove the tumour in the bone. If surgery is not possible, radiotherapy may be used instead. Chemotherapy is used for most people with an osteosarcoma. It is often given to shrink the tumour before surgery.
Major improvements have been made in surgery| for bone cancer. In the past, it was often necessary to remove the limb if cancer was found. Now, however, it is often possible just to remove the affected part of the bone and some of the healthy tissue around it. The bone is then replaced with a specially designed metal replacement (prosthesis) or a bone graft (bone taken from another part of the body). If the cancer affects a bone in or near a joint the whole joint can often be replaced with an artificial one. These operations are known as limb-sparing surgery.
Unfortunately, it is not always possible to use limb-sparing surgery and sometimes removing the whole of the affected limb (amputation) may be the only way to treat the cancer. This is often due to the cancer spreading from the bone into the nerves and blood vessels around it.
The type of surgery you have will depend on a number of factors. Your surgeon will discuss the different types of surgery with you before any decision is made about your treatment.
It is often helpful to talk to someone who has had the same operation as you are going to have. The medical and nursing staff will be able to arrange this for you. On some wards a special counsellor may be available to discuss any worries you may have.
Chemotherapy| is the use of anti-cancer (cytotoxic) drugs to destroy cancer cells. This is an important treatment for most people with osteosarcoma as it can greatly improve the results of surgical treatment. It is usually given before surgery and may shrink large tumours enough to avoid the need for amputation. The course of chemotherapy continues after surgery in order to destroy any remaining cancer cells and stop the sarcoma from spreading outside the bone – this is known as adjuvant chemotherapy.
Chemotherapy can make you feel better by relieving the symptoms of the cancer, but it can sometimes have unpleasant side effects. Any side effects that occur can often be controlled well with medicines.
Radiotherapy| treats cancer by using high-energy rays that destroy the cancer cells, while doing as little harm as possible to normal cells. Osteosarcomas are not very sensitive to radiation treatment, so radiotherapy is not often used to treat this type of tumour. However, it may be given after surgery to destroy any remaining cancer cells or if a limb has fractured and the risk of the cancer spreading is increased, especially into the surrounding tissues.
Radiotherapy can cause general side effects such as feeling sick (nausea)| and tiredness|. These side effects can be mild or more troublesome, depending on the strength of the radiotherapy dose and the length of your treatment. The radiotherapist will be able to advise you what to expect.
Research into new ways of treating osteosarcoma is going on all the time. Cancer doctors use clinical trials| to assess new treatments. These are especially important for finding improvements in treatment for rare cancers. Currently, one of the main trials for osteosarcoma is the EURAMOS 1 study. Your specialist can tell you more about this. Before any trial is allowed to take place, it must have been approved by an ethics committee, which protects the interests of the patients taking part.
If you decide to take part in a trial, your doctor or a research nurse must discuss the treatment with you so that you have full understanding of the trial and what it means to take part. You may decide not to take part or withdraw from a trial at any stage and will then receive the best standard treatment available.
After your treatment is completed, you will have regular check-ups and x-rays. These will continue for several years. If you have any problems, or notice any new symptoms in between these times, let your doctor know as soon as possible.
The need for practical and emotional support will vary from person to person. It may depend on the treatment you receive and any side effects the treatment may cause. Your specialist will inform you of any potential side effects and how to deal with them before you agree to treatment.
Many different emotions| may affect you. Anger, guilt, anxiety and fear are some of the most common feelings that people have. You may find yourself tearful, restless and unable to sleep. You may have feelings of hopelessness and depression. These are all normal reactions, but it is often difficult and distressing to admit to them.
You do not have to cope with these feelings on your own and there are people available to help you. You may find it helpful to talk to your family and friends about how you feel. Some hospitals have their own emotional support services with specially-trained staff, and some of the nurses on the ward will have received training in counselling. You may feel more comfortable talking to a counsellor outside the hospital environment or to a religious leader.
Our cancer support service| can put you in touch with counselling services in your area or see our list of counselling organisations|.
This section has been compiled using information from a number of reliable sources, including:
For further references, please see general bibliography|.
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