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Pamidronate, can be used when cancer has spread to the bones|. Get information about pamidronate, how it is given and some of its possible side effects.
You’ll see your doctor regularly while you have this treatment so they can monitor its effects. This information should help you to discuss any queries about your treatment and its side effects with your doctor or specialist nurse.
Pamidronate belongs to a group of drugs called bisphosphonates|. Bisphosphonates are commonly used to treat bone thinning (osteoporosis). In certain situations, they can help protect your bones against some of the effects of secondary bone cancer|, such as pain and weakness. Secondary bone cancer occurs when cells from the original (primary) cancer spreads to form a new tumour (secondary cancer or metastasis) in the bone.
In secondary bone cancer, calcium, which helps strengthen the bones, can be lost from the damaged bone and seep into the bloodstream. A raised level of calcium in the blood is known as hypercalcaemia|. This can cause symptoms such as feeling or being sick (nausea or vomiting), tiredness, irritability and sometimes confusion. Pamidronate can help reduce high levels of calcium.
Secondary cancer in the bones may make them weak, and in some situations they may fracture or break. Pamidronate can help to re-strengthen the bone and reduce the risk of fractures.
Cancer can affect the bones in different ways, and pamidronate is not helpful for all cancers that affect the bones. Your doctor or specialist nurse can tell you if it would be helpful for you.
Myeloma and some secondary bone cancers can produce chemicals that make the osteoclasts work harder. This means that more bone is destroyed than rebuilt, which leads to weakening of the affected bone. This can cause pain and means that the bone can fracture or break more easily.
Pamidronate targets areas of bone where the osteoclast activity is high. It helps bring the balance of osteoclast and osteoblast activity back to normal by reducing the activity of the osteoclasts. This can reduce pain and help strengthen the bone. It also means that less calcium will be lost from the bones.
Pamidronate is given by a drip (infusion) into a vein through a fine tube called a cannula. It can usually be given in the outpatient department at the hospital. The infusion is given over several hours every 3-4 weeks.
If you are having pamidronate to reduce pain, or strengthen your bones, then you may need to take it for as long as it seems to be working.
Pamidronate to lower calcium levels is usually given in a single 'one-off' dose. This dose can also be given over 2-4 days as multiple infusions.
Some people have very few side effects while others may experience more. The side effects described below won't affect everyone who is having pamidronate and may be different if you're having more than one drug.
We have outlined the most common side effects but haven't included those that are rare and therefore unlikely to affect you. If you notice any effects that aren't listed below, discuss them with your doctor or nurse.
Sometimes pain| in the affected bone can temporarily become worse when you first take pamidronate. If this happens, your doctor can prescribe painkillers until this side effect wears off.
This can happen if the calcium levels in the blood drops below normal. This is rare and usually only temporary. Your doctor will carry out regular blood tests to monitor the level of calcium in your blood.
This is usually mild and can be controlled with anti-sickness (anti-emetic)| tablets.
This can usually be controlled with medicine, but let your doctor know if it is severe or continues.
A rare side effect of pamidronate is a condition called osteonecrosis of the jaw. This is when healthy bone tissue in the jaw becomes damaged and dies. Gum disease, problems with your dentures and some dental treatments, such as having a tooth removed, can increase the risk of this. So before you start taking the drug you'll be advised to have a full dental check-up.
During treatment with bisphosphonates, it's very important to look after your teeth by brushing them regularly and having routine dental check-ups. Always let your dentist know that you're taking bisphosphonates. Some of the symptoms of osteonecrosis can include pain, swelling, redness of the gums, loose teeth or a feeling of numbness or heaviness in your jaw. Tell your cancer specialist and dentist straight away if you have any of these symptoms.
If you’re admitted to hospital for a reason not related to the cancer, it’s important to tell the doctors and nurses looking after you that you’re having treatment with bisphosphonates. You should tell them the name of your cancer specialist so that they can ask for advice.
It’s a good idea to know who you should contact if you have any problems or troublesome side effects when you’re at home.
This section has been compiled using information from a number of reliable sources, including:
Thanks to Debbie Wright, Lead Pharmacist Cancer Care, and the people affected by cancer who reviewed this edition. Reviewing information is just one of the ways you could help when you join our Cancer Voices network|.
Content last reviewed: 1 January 2013
Next planned review: 2015
For answers, support or just a chat, call the Macmillan Support Line free (Monday to Friday, 9am-8pm)
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© Macmillan Cancer Support 2013
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