This information is about a chemotherapy treatment for Hodgkin lymphoma called ChlVPP.
The drugs that are used
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ChlVPP is named after the initials of the drugs used, which are
How treatment is given
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ChlVPP chemotherapy is usually given to you as a day patient. Before you start treatment you'll need a blood test – either on the same day or a few days beforehand. You'll also be seen by a doctor, specialist nurse or pharmacist. If the results of your blood test are normal, the pharmacy will prepare your chemotherapy drugs. This may take a couple of hours.
The nurse will insert a thin, flexible tube (cannula) into a vein in your hand or arm. You may find this uncomfortable or a little painful, but it shouldn't take long. Some people have their chemotherapy given through a thin, plastic tube inserted under the skin and into a vein near the collarbone (central line), or passed through a vein in the crook of their arm (PICC line). Your doctor or nurse will explain more about this to you.
You'll be given an anti-sickness (anti-emetic) drug as a tablet or by injection through the cannula, central line or PICC line, which is connected to a drip (infusion).
The anti-sickness drug is followed by a small infusion of vinblastine (a colourless fluid). The infusion takes about 5–10 minutes. Your cannula will be removed after this.
If you have a central or PICC line it will usually stay in place, ready for the next cycle of your chemotherapy. You'll be shown how to look after the line.
The rest of your drugs are taken as tablets or capsules. You'll be given chlorambucil, procarbazine and prednisolone to take at home. It's important to take all the tablets or capsules as prescribed by your doctor.
You'll be given a supply of anti-sickness (anti-emetic) tablets to take home with you. It is important to take these as directed even if you aren't feeling sick. This is because some anti-sickness drugs are much better at preventing sickness than stopping it once it starts.
How often treatment is given
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Your doctor may use the word 'regimen' (eg the ChlVPP regimen) when talking about your chemotherapy. This refers to the whole plan or schedule of your particular chemotherapy treatment.
On the first day of your treatment (day 1), you'll be given an infusion of vinblastine (as described above). You'll also begin a two-week course of chlorambucil, procarbazine and prednisolone, which are all taken as tablets or capsules. A week after your treatment starts (day 8) you'll be given a second infusion of vinblastine. After you have finished all your tablets, you'll have a rest period with no chemotherapy for the next two weeks. This completes what is called a cycle of your treatment. Each cycle takes four weeks (28 days).
After the rest period the treatment will be repeated; beginning the next cycle of your chemotherapy. Usually 6–8 cycles are given over a period of 6–8 months. This makes up a course of treatment.
Each person’s reaction to chemotherapy is different. Some people have very few side effects while others may experience more. The side effects described here won't affect everyone who is having ChlVPP chemotherapy.
We have outlined the most common side effects but haven't included those that are rare and unlikely to affect you. If you notice any effects that aren't listed here, discuss them with your doctor, chemotherapy nurse or pharmacist.
Risk of infection
ChlVPP can reduce the number of white blood cells, which help fight infection. White cells are produced by the bone marrow. If the number of your white blood cells is low you'll be more prone to infections. A low white blood cell count is called neutropenia.
Neutropenia begins seven days after treatment. Your resistance to infection is usually at its lowest 10–14 days after chemotherapy. The number of your white blood cells will then increase steadily and usually return to normal before your next cycle of chemotherapy is due.
Contact your doctor or the hospital straight away if:
your temperature goes above 38°C (100.4°F)
you suddenly feel unwell even with a normal temperature.
You'll have a blood test before having more chemotherapy to check the number of white blood cells. Occasionally, your treatment may need to be delayed if the number of your blood cells (blood count) is still low.
Bruising and bleeding
ChlVPP can reduce the production of platelets, which help the blood to clot. Tell your doctor if you have any unexplained bruising or bleeding, such as nosebleeds, bleeding gums, blood spots or rashes on the skin. You may need to have a platelet transfusion if your platelet count is low.
ChlVPP can reduce the number of red blood cells, which carry oxygen around the
body. A low red blood cell count is called anaemia. This may make you feel tired and breathless. Tell your doctor or nurse if you have these symptoms. You may need
to have a blood transfusion if the number of red blood cells becomes too low.
Feeling tired is a common side effect of chemotherapy, especially towards the end of treatment and for some weeks after it’s over. It’s important to try to pace yourself and get as much rest as you need. Try to balance this with some gentle exercise, such as short walks, which will help. If tiredness is making you feel sleepy, don’t drive or operate machinery.
This usually starts 3–4 weeks after starting treatment, although it may occur earlier. Hair usually falls out completely. You may also have thinning and loss of eyelashes, eyebrows and other body hair. This is temporary and your hair will start to grow again once the treatment has finished. Your hair may grow back straighter, curlier, finer, or a slightly different colour than it was before. Your nurse can give you advice about coping with hair loss.
Your mouth may become sore or dry, or you may notice small ulcers during this treatment. Drinking plenty of fluids, and cleaning your teeth regularly and gently with a soft toothbrush, can help reduce the risk of this happening. Some people may find sucking on ice soothing. Tell your nurse or doctor if you have any of these problems, as they can prescribe mouthwashes and medicine to prevent or clear mouth infections.
You may notice that food tastes different. Normal taste usually comes back after treatment finishes. A dietitian or specialist nurse at your hospital can give you advice about ways of coping with this side effect.
Irritation of the stomach lining
Prednisolone can irritate the lining of the stomach and may cause a stomach ulcer or make one worse. You should take the tablets with a meal or a drink of milk to reduce this side effect. Tell your doctor if you have indigestion, or pain or discomfort in the tummy (abdomen). You may be prescribed medication to reduce irritation of the stomach.
Appetite changes and weight gain
You may notice you feel hungrier than usual while taking prednisolone, and this can make you want to eat more. If you’re concerned about gaining weight, you can speak to your doctor, specialist nurse or dietitian.
Numbness or tingling in the hands or feet
This is due to the of vinblastine on on nerves and is known as peripheral neuropathy. You may also notice that you have difficulty doing up buttons or similar fiddly tasks.
Tell your doctor if you notice any numbness or tingling in your hands or feet. It's important to report your symptoms to your doctor as they may be controlled by slightly lowering the dose of the drug.
This side effect usually improves slowly a few months after the treatment has finished. Sometimes symptoms can persist, talk to your doctor if this happens.
Prednisolone may affect the salt and water balance in your body. You may notice that your ankles and/or fingers swell. Some people have a bloated feeling in the abdomen. Let your doctor know if this happens. This is usually only a problem with long-term steroid treatment.
You may develop flu-like symptoms a few hours after you have had procarbazine. These include headaches, aching joints or muscles, a high temperature, lack of energy (lethargy) and chills. If this happens, it's important to drink plenty of fluids and get some rest. If these symptoms continue for more than a day contact your doctor.
Less common side effects
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Raised blood sugar
Occasionally, prednisolone can cause your blood sugar level to rise. During treatment you’ll have regular blood tests to check this. Your urine may also be tested for sugar.
Tell your doctors if you get very thirsty or if you’re passing more urine than usual. This can be a sign that your blood sugar level is rising.
ChlVPP can cause diarrhoea. This can usually be easily controlled with medicine, but tell your doctor if it's severe or continues. It's important to drink plenty of fluids if you have diarrhoea.
A skin rash can sometimes occur while you're having treatment with procarbazine. It’s important to let your doctor know if this happens. Your doctor can prescribe medicine to help with this.
Rarely, your skin may darken. If it does, it usually goes back to normal a few months after the treatment has finished. During treatment and for several months afterwards, you'll be more sensitive to the sun and your skin may burn more easily than normal. You can still go out in the sun but should wear a suncream with a high sun protection factor (SPF), and cover up with clothing and a hat.
Sometimes areas of skin that have been treated with radiotherapy may become red and sore. Tell your doctor if this happens.
Behavioural changes and mood swings
Occasionally, prednisolone can cause mood swings, difficulty sleeping and anxiety or irritability. Let your doctor know if there are any changes in your behaviour that are worrying you. Difficulty with sleeping may be helped by taking the steroids in the early part of the day, but discuss this with your doctor first.
It’s important to let your doctor know straight away if you feel unwell or have any severe side effects, even if they’re not mentioned above.
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Risk of developing a blood clot
Cancer can increase the risk of developing a blood clot (thrombosis), and chemotherapy may increase this risk further.
A blood clot may cause symptoms such as pain, redness and swelling in a leg, or breathlessness and chest pain. Blood clots can be very serious, so it’s important to tell your doctor straight away if you notice any of these symptoms. Most clots can be treated with drugs that thin the blood. The doctor or nurse can give you more information.
Some medicines, including those you can buy in a shop or chemist, can be harmful to take when you're having chemotherapy. Tell your doctor about any medicines you're taking, including over-the-counter drugs, complementary therapies and herbal drugs.
Leakage into the tissue around the vein (extravasation)
If this happens when vinblastine is being given, the tissue in that area can become damaged. Tell the doctor or nurse immediately if you notice any stinging or burning around the vein while the drug is being given. This is unlikely to happen if the chemotherapy is given through a central or PICC line.
If the area around the injection site becomes red or swollen at any time, you should tell the doctor or nurse on the ward. If you're at home, ring the clinic or ward and ask to speak to the doctor or nurse.
Rarely, procarbazine (or procarbazine containing regimens) may interact with certain drinks and foods causing sickness, headaches, sweating, drowsiness and breathing problems. You may need to avoid red wine, alcohol and alcohol-free beers, mature cheeses, certain meats (salami, pepperoni) and yeast or beef extracts (OXO®, Bovril® and Marmite®). Your nurse or doctor will give you more advice on which foods to avoid.
Anyone who has Hodgkin lymphoma should be given blood and platelet transfusions that have been treated with radiation (irradiated). This lowers the risk of the donated blood cells reacting against your own. Your hospital team should give you a card to carry or a Medicalert® to wear so hospital staff are aware in case of an emergency.
Your ability to become pregnant or father a child is likely to be affected by having this treatment. It's important to discuss fertility with your doctor before starting treatment.
It's not advisable to become pregnant or father a child while having ChlVPP as it may harm the developing baby. It’s important to use effective contraception while taking this drug and for at least a few months afterwards. You can discuss this with your doctor.
It’s not known whether chemotherapy drugs can be present in semen or vaginal fluids. To protect your partner, it’s safest to either avoid sex or use a barrier form of contraception for about 48 hours after chemotherapy.
There's a potential risk that chemotherapy drugs may be present in breast milk. Women are advised not to breastfeed during chemotherapy and for a few months afterwards.
Loss of periods in women
Due to the effect of chemotherapy on the ovaries, women may find that their periods become irregular and may eventually stop. In some women this may be temporary, but for others it will be permanent. This will result in menopausal symptoms, such as hot flushes, sweats and vaginal dryness.
If you’re admitted to hospital for a reason not related to the cancer, it’s important to tell the doctors and nurses looking after you that you're having chemotherapy treatment. You should tell them the name of your cancer specialist so they can ask for advice.
It’s a good idea to know who you should contact if you have any problems or troublesome side effects when you’re at home. Your chemotherapy nurse or doctor will give you details of who to contact for advice. This should include ‘out-of hours’ contact details if you need to call someone at evenings, overnight or at the weekend.
Things to remember about your medicines
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It’s important to take your tablets and capsules at the right times as directed by your doctor.
Always tell any doctors treating you for non-cancerous conditions that you're taking a course of chemotherapy that shouldn't be stopped or restarted without advice from your cancer specialist.
Keep the medicines in their original packaging. Store the procarbazine and prednisilone capsules and tablets at room temperature away from heat and direct sunlight. The chlorambucil tablets should be kept dry and stored in the refrigerator.
Keep the tablets and capsules in a safe place and out of the reach of children.
If your doctor decides to stop the treatment, return any remaining tablets and capsules to the pharmacist. Don't flush them down the toilet or throw them away.
If you're sick just after taking your tablets or capsules, let your doctor or chemotherapy nurse know. You may need to take another dose. Don't take another capsule or tablet without telling your doctor first.
If you forget to take a tablet or capsule, don't take a double dose. Let your doctor know and keep to your regular dose schedule.
This section is based upon our ChlVPP chemotherapy fact sheet, which has been compiled using information from a number of reliable sources including:
Sweetman, et al. Martindale: The Complete Drug Reference. 37th edition. 2011. Pharmaceutical Press.
British National Formulary. 62nd edition. 2011. British Medical Association and Royal Pharmaceutical Society of Great Britain.
electronic Medicines Compendium (eMC). (accessed October 2011).
Perry MC. The Chemotherapy Source Book. 4th edition. 2007. Lippincott Williams and Wilkins.