Leucovorin is not a chemotherapy drug. It is often given as part of chemotherapy treatment to increase effectiveness or reduce side effects.
It should ideally be read with our general information about chemotherapy and the type of cancer you have.
Adding leucovorin has been shown to increase the effectiveness of 5FU. Leucovorin may also be given with the chemotherapy drug tegafur-uracil (Uftoral®), which is similar to 5FU.
Leucovorin is commonly given with methotrexate, which is used to treat many different types of cancer. It's mainly given with higher doses of methotrexate and can help reduce the side effects. It is sometimes known as folinic acid rescue or leucovorin rescue.