EOX

This information is about EOX, a combination of chemotherapy drugs used to treat cancer of the gullet (oesophagus) and of the stomach.

EOX is given into a vein and as tablets. You have it as an outpatient or during a hospital stay. Your cancer doctor or nurse will tell you how often you will have it.

Like all chemotherapy EOX can cause side effects, some of which can be serious so it’s important that you read the detailed information below. How chemotherapy affects people varies from person to person. It’s important to read about the side effects so that you know what to expect. Your healthcare team can talk to you more about this and give you advice on how to manage any side effects. Our more detailed information on chemotherapy may also be helpful.

Tell your doctor or nurse straight away if you have a temperature, feel unwell or have severe side effects, including any we don’t mention here. And if you need to seek medical attention for any reason other than cancer, always tell the healthcare staff that you are having chemotherapy.

What is EOX?

EOX is a chemotherapy treatment that is used to treat cancer of the gullet (oesophagus) and of the stomach.

This information is best when read with our general information about chemotherapy and the type of cancer you have.

The drugs used in EOX

EOX comes from the initials of the drugs used in the treatment. The drugs are:

You might hear the treatment called EEX because the other name for oxaliplatin is Eloxatin®.


How EOX is given

You will have EOX in the chemotherapy day unit or during a short stay in hospital. A chemotherapy nurse will give it to you. During treatment, you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse. This is who we mean when we mention doctor or nurse in this information.

Before or on the day of treatment, a nurse or person trained to take blood (phlebotomist) will take a blood sample from you. This is to check that it is okay for you to have chemotherapy.

You will also see a doctor or nurse before you have chemotherapy. They will ask you about how you have been. If your blood results are all right on the day of your treatment, the pharmacist will prepare your chemotherapy. Your nurse will tell you when your treatment is likely to be ready.

Your nurse will give you anti-sickness (anti-emetic) drugs as an injection into a vein or as tablets. Injections and drips are given through one of the following:

  • a short thin tube that the nurse puts into a vein in your arm or hand (cannula)
  • a fine tube that goes under the skin of your chest and into a vein close by (central line)
  • a fine tube that is put into a vein in your arm and goes up into a vein in your chest (PICC line).

Your nurse will give you epirubicin (a red fluid) as an injection directly into your vein with a drip (infusion) to flush it through. After this, they will give you oxaliplatin as a drip. They usually give the drip through a pump, which gives you the treatment over two hours.

You have capecitabine as tablets, which you take at home.

When the chemotherapy is being given

Some people might have side effects while they are having the chemotherapy:

Allergic reaction

Rarely, oxaliplatin may cause an allergic reaction while it’s being given. Your nurse will check you for this. If you have a reaction, they will treat it quickly. Signs of a reaction can include:

  • a rash
  • feeling itchy, flushed or short of breath
  • swelling of your face or lips
  • feeling dizzy
  • having pain in your tummy, back or chest
  • feeling unwell.

Tell your nurse straight away if you have any of these symptoms.

The drug leaks outside the vein

If this happens when you’re having epirubicin or oxaliplatin, it can damage the tissue around the vein. This is called extravasation. Tell the nurse straight away if you have any stinging, pain, redness or swelling around the vein. Extravasation is not common, but if it happens it’s important that it’s dealt with quickly.

If you get any of these symptoms after you get home, contact the doctor or nurse straight away on the number they gave you.

Pain along the vein

If you have this, tell your nurse straight away. They will check your drip site and slow the drip to ease the pain.

Facial flushing

You may suddenly feel warm and your face may get red while the epirubicin is being given. This should only last a few minutes.

Taking your chemotherapy tablets

Before you leave hospital, the nurse or pharmacist will give you chemotherapy tablets to take when you are at home. Always take your tablets exactly as explained. This is important to make sure they work as well as possible for you.

You take capecitabine tablets twice a day. Swallow them whole with a glass of water within half an hour of eating a meal. Capecitabine works best if it's broken down in the stomach with food. Take them in the morning after breakfast and then after your evening meal. Make sure the doses are at least 10–12 hours apart.

Tell your doctor if you find it difficult to swallow the tablets. They may suggest that you dissolve the capecitabine tablets in water. In this case, dissolve the tablets in a 200ml glass of warm water, stir with a spoon until the tablets are completely dissolved and then drink it immediately. The glass and spoon should be washed and kept separate from your other crockery and cooking utensils.

If you are sick just after taking the tablets, contact the hospital. You may need to take another dose. If you forget to take a tablet, do not take a double dose. Keep to your regular schedule and let your doctor or nurse know.

Other things to remember about your tablets:

  • Keep them in the original package at room temperature away from heat and direct sunlight.
  • Keep them safe and out of the reach of children.
  • Return any remaining tablets to the pharmacist if your treatment is stopped.

Your course of EOX

You have chemotherapy as a course of several sessions (or cycles) of treatment over a few months. Each cycle of EOX takes 21 days (three weeks).

On the first day, you will have epirubicin and oxaliplatin and start taking the 21-day course of capecitabine tablets. You will take these every day of your treatment.

At the end of the 21 days, you will start your second cycle of EOX. This is exactly the same as the first cycle. You have up to eight cycles over 24 weeks. Your doctor or nurse will tell you the number of cycles you are likely to have.

Going home

Before you go home, the nurse or pharmacist will also give you anti-sickness drugs to take. They may also give you anti-diarrhoea tablets if you need them. Take all your tablets exactly as they have been explained to you.


Possible side effects of EOX

We explain the most common side effects of EOX here. But we don’t include all the rare ones that are unlikely to affect you.

You may get some of the side effects we mention, but you are very unlikely to get all of them. Always tell your doctor or nurse about the side effects you have. Your doctor can prescribe drugs to help control some of these.

It is very important to take the drugs exactly as your nurse or pharmacist has explained. This means they will be more likely to work better for you.

Your nurse will give you advice about managing your side effects. After your treatment is over, the side effects will start to improve.

Serious and life-threatening side effects

Sometimes cancer drugs can result in very serious side effects, which rarely may be life-threatening. Your cancer doctor and nurse can explain the risk of these side effects to you

Contact the hospital

Your nurse will give you telephone numbers for the hospital. You can call them if you feel unwell or need advice any time of day or night. Save these numbers in your mobile phone or keep them somewhere safe.

More information about these drugs

We’re not able to list every side effect for this treatment here, particularly the rarer ones. For more detailed information you can visit the electronic Medicines Compendium (eMC).

Risk of infection

EOX can reduce the number of white blood cells in your blood. This will make you more likely to get an infection. When the number of white blood cells is low, it’s called neutropenia.

Contact the hospital straight away on the contact number you’ve been given if:

  • your temperature goes over 37.5°C (99.5°F) or over 38°C (100.4°F), depending on the advice given by your chemotherapy team
  • you suddenly feel unwell, even with a normal temperature
  • you have symptoms of an infection – this can include feeling shaky, a sore throat, a cough, diarrhoea or needing to pass urine a lot.

The number of white blood cells usually increases steadily and returns to normal before your next treatment. You will have a blood test before having more chemotherapy. If your white blood cells are still low, your doctor may delay your treatment for a short time

Bruising and bleeding

EOX can reduce the number of platelets in your blood. Platelets are cells that help the blood to clot. Tell your doctor if you have any bruising or bleeding you can’t explain. This includes nosebleeds, bleeding gums, blood spots or rashes on the skin.

Anaemia (low number of red blood cells)

EOX can reduce the number of red blood cells in your blood. These cells carry oxygen around the body. If the number of red blood cells is low, you may be tired and breathless. Tell your doctor or nurse if you feel like this. If you are very anaemic, you may need a drip to give you extra red blood cells (blood transfusion).

Feeling sick

Your doctor will prescribe anti-sickness (anti-emetic) drugs to help prevent or control sickness. Take the drugs exactly as your nurse or pharmacist explains to you. It’s easier to prevent sickness than to treat it after it has started.

If you still feel sick or are vomiting, contact the hospital as soon as possible. They can give you advice and change the anti-sickness drug to one that works better for you.

Tiredness

Feeling very tired is a common side effect. It’s often worse towards the end of treatment and for some weeks after. Try to pace yourself and get as much rest as you need. It helps to balance this with some gentle exercise, such as short walks. If you feel sleepy, don’t drive or operate machinery.

Diarrhoea

This can sometimes be severe. Your doctor can prescribe anti-diarrhoea drugs to control it. You may be given these before you leave hospital. It’s important to take them exactly as your nurse or pharmacist explains. Make sure you drink at least two litres (three and a half pints) of fluids every day if you have diarrhoea.

If you have diarrhoea more than 4–6 times a day, or at night, contact the hospital straight away on the numbers your nurse gave you. Your doctor may ask you to stop taking capecitabine. When the diarrhoea is better, they will tell you if you can start taking it again. Sometimes they reduce the dose.

Constipation

Oxaliplatin may make you constipated and cause tummy pain. Drinking at least two litres (three and a half pints) of fluids every day will help. Try to eat more foods that contain fibre (such as fruit, vegetables and wholemeal bread) and do some regular, gentle exercise.

Sore mouth

Your mouth may become sore and you may get ulcers. This can make you more likely to get an infection in your mouth. Gently clean your teeth and/or dentures morning and night and after meals. Use a soft-bristled or children’s toothbrush. Your nurse might ask you to rinse your mouth regularly or use mouthwashes. It’s important to follow any advice you are given and to drink plenty of fluids.

Tell your nurse or doctor if you have any problems with your mouth. They can prescribe medicines to prevent or treat mouth infections and reduce any soreness.

Hair loss

You usually lose all the hair on your head. Your eyelashes, eyebrows and other body hair may also thin or fall out. This usually starts after your first or second cycle of chemotherapy. It is almost always temporary and your hair will grow back after chemotherapy ends. It is important to cover your head to protect your scalp when you are out in the sun until your hair grows back. Your nurse can give you advice about coping with hair loss.

Skin changes

EOX may affect your skin. Your doctor or nurse can tell you what to expect. If your skin feels dry, try using an unperfumed moisturising cream every day. During treatment and for several months afterwards, you'll be more sensitive to the sun and your skin may burn more easily than usual. You can still go out in the sun, but use a suncream with a sun protection factor (SPF) of at least 30, and cover up with clothing and a hat.

Your skin may darken. It will return to its normal colour after you finish treatment. If you’ve had radiotherapy, either recently or in the past, the area that was treated may become red or sore.

Always tell your doctor or nurse about any skin changes. They can give you advice and may prescribe creams or medicines to help. Any changes to your skin are usually temporary and improve when treatment finishes.

Soreness and redness of palms of hands and soles of feet

This is called palmar-plantar or hand-foot syndrome. It gets better when treatment ends. Your doctor or nurse may prescribe creams to improve the symptoms. It can help to keep your hands and feet cool and to avoid tight-fitting socks, shoes and gloves.

Numb or tingling hands or feet

These symptoms are caused by the effect of oxaliplatin on the nerves. It’s called peripheral neuropathy. You may find it hard to fasten buttons or do other fiddly tasks.

Tell your doctor if you have these symptoms. They sometimes need to lower the dose of the drug. The symptoms usually improve slowly after treatment finishes, but in some people they may never go away. Talk to your doctor if you are worried about this.

Nail changes

Your nails may become brittle and break easily. They may get darker or discoloured, and/or you may get lines or ridges on them. These changes grow out after treatment finishes. Wearing gloves when washing dishes or using detergents will help protect your nails during treatment.

Discoloured urine

Your urine may become a pink-red colour for up to 48 hours after you’ve had the treatment. This is normal and due to the colour of epirubicin.

Eye problems

Your eyes may become watery and feel sore and may become more sensitive to light. Your doctor can prescribe eye drops to help with this. If your eyes get red and inflamed (conjunctivitis), tell your doctor. This is because you may need anti-biotic eye drops.

EOX may also cause blurry vision and/or eye pain. Always tell your doctor or nurse if you have eye pain or notice any change in your vision.

Headaches

If you have headaches, tell your doctor or nurse. They can give you painkillers to help.


Less common side effects of EOX

Breathing and swallowing

Oxaliplatin can affect the area around the voicebox (larynx). This can make it feel difficult to swallow or to breathe. This can feel very frightening, but only lasts a short while. Try taking long deep breaths through your nose to help your breathing get back to normal. The symptoms can be made worse by cold temperatures. Avoid having cold drinks or ice cubes for a few days after treatment.

It’s important to tell your doctor or nurse if you have this side effect. They can give you the oxaliplatin over a longer time (4–6 hours) to reduce the chance of this happening.

Hearing changes

Some people may have pain or ringing in their ears (tinnitus). Rarely, oxaliplatin may cause some hearing loss. Tell your doctor if you notice any changes to your hearing.

Changes in the way the heart works

Epirubicin can affect the way the heart works. You may have tests to see how well your heart is working before, during and sometimes after treatment.

If you have pain or tightness in your chest, feel breathless, or notice changes to your heartbeat at any time during or after treatment, tell a doctor straight away. These symptoms can be caused by other conditions, but it’s important to get them checked by a doctor.

It’s important to tell your doctor or nurse straight away if you feel ill or have severe side effects. This includes any we don’t mention here.


Other information about EOX

Blood clot risk

Cancer increases the chance of a blood clot (thrombosis) and chemotherapy can add to this. A clot can cause symptoms such as pain, redness and swelling in a leg, breathlessness and chest pain. Contact your doctor straight away if you have any of these symptoms. A blood clot is serious, but your doctor can treat it with drugs that thin the blood. Your doctor or nurse can give you more information.

Other medicines

EOX may interact with different drugs. It may also affect the way blood thinning drugs, such as warfarin, work. The vitamin folic acid can increase the side effects of capecitabine.

Medicines you can buy in a shop or chemist may also be harmful when you are having chemotherapy. Tell your doctor about any medicines you are taking, including over-the-counter drugs, complementary therapies and herbal drugs.

Fertility

EOX may affect your fertility (being able to get pregnant or father a child). If you are worried about this, you can talk to your doctor or nurse before treatment starts.

Contraception

Your doctor will advise you not to become pregnant or to father a child during treatment. This is because the drugs may harm a developing baby. It’s important to use effective contraception during and for a few months after chemotherapy. You can talk to your doctor or nurse about this.

Sex

If you have sex within the first couple of days of having chemotherapy, you need to use a condom. This is to protect your partner in case there is any chemotherapy in your semen or vaginal fluid.

Changes to your periods

EOX can sometimes stop the ovaries working. You may not get a period every month and they may eventually stop. In some women this is temporary, but for others it is permanent and they start the menopause.

Breastfeeding

Women are advised not to breastfeed during treatment and for a few months after. This is in case there is chemotherapy in their breast milk.

Medical and dental treatment

If you need to go into hospital for any reason other than cancer, always tell the doctors and nurses that you are having chemotherapy. Explain you are taking chemotherapy tablets that no one should stop or restart without advice from your cancer doctor. Give them the contact details for your cancer doctor.

Talk to your cancer doctor or nurse if you think you need dental treatment. Always tell your dentist you are having chemotherapy.