Browser does not support script.
Skip to main content
Find out how we produce our information|
Acute myeloid leukaemia (AML) can be divided (or classified) into different sub-types. This is important as different types of AML are treated in different ways. Your doctors need to know which type you have to help them plan the most appropriate treatment| for you.
Your bone marrow sample| will be tested to find out which type of AML you have. Different types of AML are associated with particular genetic changes. So the following tests can help doctors decide on the best treatment and predict how well the leukaemia may respond to it.
This involves testing the leukaemia cells with antibodies to look for specific proteins on their surface. It helps doctors identify what type of cell has become abnormal.
This is the study of chromosomes. Almost all the cells in our bodies contain chromosomes, which are made up of genes|. The genes control all the activities of the cell. With leukaemia, there are often changes in the structure of the chromosomes in the leukaemia cells, but not in the normal cells. A cytogenetic test on the bone marrow sample looks for these changes.
This test is used to look for specific changes in the chromosomes that can’t be seen with cytogenetic testing.
This is a very sensitive test that can identify chromosome changes that are too small to see under a microscope. PCR testing may also be done after treatment| to check how well it has worked.
In the UK, doctors usually classify AML according to the World Health Organisation (WHO) system and the French American British (FAB) system.
The WHO system classifies AML according to the type of cell that has become abnormal and whether:
The WHO system is important as it’s useful for planning treatment and predicting response.
The FAB system looks at the appearance of the leukaemia cells under a microscope (morphology). Each type of AML is named according to the cell type and given a number from M0–M7. Doctors may classify AML with the FAB system while waiting for the results of other tests.
Content last reviewed: 1 February 2013
Next planned review: 2015
For answers, support or just a chat, call the Macmillan Support Line free (Monday to Friday, 9am-8pm)
If you have any questions about cancer, need support or just want someone to talk to, ask Macmillan.
If you have any questions about Macmillan we would love to hear from you| .
You can also follow us| on Facebook, Twitter, Flickr or YouTube.
© Macmillan Cancer Support 2013
what are these?|