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Macmillan and Cancerbackup merged in 2008. Together we provide free, high quality information for people affected by cancer through our publications, website and phone service. Find out more|.
Find out how we produce our information|
This information is about a hormonal therapy| called triptorelin, which is used to treat prostate cancer|. Throughout this information we refer to it by its more commonly used name, triptorelin.
This information should ideally be read with our general information about prostate cancer|.
You will see your doctor regularly while you have this treatment so they can monitor its effects.
Triptorelin is a type of hormonal therapy used to treat advanced prostate cancer|. You will see your doctor regularly while you have this treatment so they can monitor its effects.
Hormonal therapies interfere with the production or action of particular hormones. Hormones are substances produced naturally in the body. They act as chemical messengers and help control the activity of cells and organs.
Most prostate cancers need supplies of the hormone testosterone to grow. Testosterone is produced by the testes and the adrenal glands.
Production of testosterone by the testes is stimulated by another hormone called luteinising hormone. This is produced by the pituitary gland, which is situated in the brain. Triptorelin reduces the production of luteinising hormone, which leads to a reduction in testosterone levels. This may shrink or slow down the development of the cancer.
You may find the injection slightly uncomfortable and may notice an area of redness or darker skin at the injection site afterwards. If you find the injection very uncomfortable, you can have a tiny amount of local anaesthetic to numb the area before the triptorelin is given.
Your doctor will discuss with you the length of treatment they feel is appropriate for your situation. Triptorelin is often given for several months or years. Treatment may continue as long as it is controlling the cancer.
Each person's reaction to any medicine is different. Many people have very few side effects while others may experience more. We have outlined the most common side effects but haven't included those that are rare and therefore unlikely to affect you.
If you notice any effects that are not listed here, discuss them with your doctor or nurse.
You may have some of the following side effects, to varying degrees:
There may be a temporary increase in testosterone levels for the first few days of triptorelin treatment. Some men may have an increase in symptoms, such as bone pain, or may have problems passing urine. Rarely, other problems may occur due to a temporary increase in the size of the tumour. This is known as tumour flare and is normal. It should improve in a few weeks. If you have any problems, let your doctor know.
Other types of hormonal therapy such as cyproterone acetate|, flutamide| or bicalutamide| may be given for the first few weeks of starting triptorelin to prevent tumour flare.
These can be common, but many people find that hot flushes| wear off after a period of time. Let your doctor know if hot flushes are causing you problems, as medicines can sometimes be prescribed to counteract them. There are a number of ways to help reduce hot flushes and sweats. Some men find it helps to cut down on tea, coffee, nicotine and alcohol.
Some people find that complementary therapies| help. Your GP may be able to give you details about having these on the NHS.
Loss of sex drive (libido) and erection difficulties (impotence) can occur. These often return to normal after stopping the drug. Some men may find that these problems carry on after treatment finishes. Talk to your doctor or nurse if these effects are a problem, as they can prescribe drugs to help. You may find our section on sexuality and cancer| helpful.
Men may sometimes notice slight breast swelling and tenderness known as gynaecomastia. Your doctor can advise you about how this can be prevented or treated.
These effects are rare, usually mild and easily controlled. Let your doctor know if you feel sick|, vomit or have diarrhoea|, as medicines can be prescribed to help.
You may be at greater risk of osteoporosis if you are taking triptorelin for longer periods of time. Your doctor can give you advice on how this can be monitored and treated. Let them know if you have any discomfort in your bones or joints. We have more information on how you can keep your bones healthy|.
There may be an increased risk of developing heart disease or diabetes when taking triptorelin. However, the benefits of hormonal treatment generally outweigh the possible risks. You can discuss the possible risks and benefits in your situation with your specialist.
Always let your doctor or nurse know about any side effects you have. There are usually ways in which they can be controlled or improved.
Missing an injection by 2-3 days should not make a great difference. But it's important to remember that the benefits of the injections are designed to last four or 12 weeks, depending on which preparation you are prescribed, so you should have them as regularly as possible.
This section has been compiled using information from a number of reliable sources including:
For answers, support or just a chat, call the Macmillan Support Line free (Monday to Friday, 9am-8pm)
If you have any questions about cancer, need support or just want someone to talk to, ask Macmillan.